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CD8 (or Cluster of Differentiation 8) is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.
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3D Structures of CD8
Updated on 24-November-2015
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- CD8
- 1cd8 – hCD8 extracellular domain – human
- CD8α
- 2hp4 - hCD8 extracellular domain (mutant)
- 1akj - hCD8 extracellular domain + class I MHC + β-2-microglobulin + HIV reverse transcriptase peptide
- 3qzw - hCD8 extracellular domain + class I MHC + β-2-microglobulin + NEF peptide
- 1bqh - mCD8 extracellular domain + class I MHC + β-2-microglobulin + VSV8 peptide - mouse
- 3dmm - mCD8 extracellular domain + class I MHC + β-2-microglobulin + peptide
- 1nez - mCD8 extracellular domain + class I MHC + β-2-microglobulin
- 1q69 - hCD8 residues 209-227 + Lck peptide - NMR
- 2arj - rCD8 extracellular domain + antibody - rat
- 2q3a – CD8 extracellular domain – rhesus monkey
- CD8α and CD8β
- 2atp - mCD8 + CD8α CD8β linker
- 3b9k - mCD8 + antibody
