CD8

spinqualitylabelsall models Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry 3b9k) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D CD8 (or Cluster of Differentiation 8) is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell. CD8α, CD8β and antibody (3b9k).

3D Structures of CD8

Updated on 24-November-2015

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• CD8
  • 3b9k – hCD8 extracellular domain – human
    
• CD8α
  • 2hp4 - hCD8 extracellular domain (mutant)
    
  • 1akj - hCD8 extracellular domain + class I MHC + β-2-microglobulin + HIV reverse transcriptase peptide
    
  • 3qzw - hCD8 extracellular domain + class I MHC + β-2-microglobulin + NEF peptide
    
  • 1bqh - mCD8 extracellular domain + class I MHC + β-2-microglobulin + VSV8 peptide - mouse
    
  • 3dmm - mCD8 extracellular domain + class I MHC + β-2-microglobulin + peptide
    
  • 1nez - mCD8 extracellular domain + class I MHC + β-2-microglobulin
    
  • 1q69 - hCD8 residues 209-227 + Lck peptide - NMR
    
  • 2arj - rCD8 extracellular domain + antibody - rat
    
  • 2q3a – CD8 extracellular domain – rhesus monkey
    
• CD8α and CD8β
  • 2atp - mCD8 + CD8α CD8β linker
    
  • 3b9k - mCD8 + antibody
    

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Michal Harel, Alexander Berchansky