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Function
CD8 (or Cluster of Differentiation 8) is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.[1]
- ↑ Devine L, Sun J, Barr MR, Kavathas PB. Orientation of the Ig domains of CD8 alpha beta relative to MHC class I. J Immunol. 1999 Jan 15;162(2):846-51. PMID:9916707
- ↑ Shore DA, Issafras H, Landais E, Teyton L, Wilson IA. The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I. J Mol Biol. 2008 Dec 31;384(5):1190-202. Epub 2008 Oct 7. PMID:18929574 doi:10.1016/j.jmb.2008.09.069
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3D Structures of CD8
Updated on 29-November-2015
{"openlevels":0}
- CD8
- 3b9k – hCD8 extracellular domain – human
- CD8α
- 2hp4 - hCD8 extracellular domain (mutant)
- 1akj - hCD8 extracellular domain + class I MHC + β-2-microglobulin + HIV reverse transcriptase peptide
- 3qzw - hCD8 extracellular domain + class I MHC + β-2-microglobulin + NEF peptide
- 1bqh - mCD8 extracellular domain + class I MHC + β-2-microglobulin + VSV8 peptide - mouse
- 3dmm - mCD8 extracellular domain + class I MHC + β-2-microglobulin + peptide
- 1nez - mCD8 extracellular domain + class I MHC + β-2-microglobulin
- 1q69 - hCD8 residues 209-227 + Lck peptide - NMR
- 2arj - rCD8 extracellular domain + antibody - rat
- 2q3a – CD8 extracellular domain – rhesus monkey
- CD8α and CD8β
- 2atp - mCD8 + CD8α CD8β linker
- 3b9k - mCD8 + antibody
References
