Dehalogenase

spinqualitylabelsall models Structure of haloalkane dehalogenase complex with I- ion (purple) (PDB code 2edc). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Dehalogenases catalyze the removal of halogen atom from substrates. • Haloalkane dehalogenase converts haloalkanes to alcohol • Halohydrin dehalogenase converts halohydrins to epoxide • L-2 haloacid dehalogenase converts L-2-haloacids to D-2-hydroxyacid • S-2 haloacid dehalogenase converts S-2-haloacids to R-2-hydroxyacid • 4-chlorobenzoyl CoA dehalogenase converts 4-chlorobenzoyl CoA to 4-hydroxybenzoyl CoA • Fluoroacetate dehalogenase converts fluoroacetate to glycolate • Iodotyrosine dehalogenase converts iodotyrosine to tyrosine • cis- and trans-3-chloroacrylic acid dehalogenase converts 3-chloroacrylate to malonate semialdehyde • 5-chloromuconolactone dehalogenase converts 5-chloromuconolactone to E-dienelactone. • Tetrachloroethene reductive dehalogenase catalyzes the conversion of trichloroethene, Cl- and acceptor to tetrachloroethene and reduced acceptor. Relevance Haloalkane dehalogenase is tested for the biodegredation of toxic industrial by-products.

3D structures of dehalogenase

Updated on 22-December-2015

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• Haloalkane dehalogenase (HDH)
  • 2had, 1ede, 2pky, 2yxp – XaHDH – Xanthobacter autotrophicus
    
  • 1hde, 1be0, 1bee, 1bez – XaHDH (mutant)
    
  • 1bn6, 1bn7, 4kaa, 4kac, 4kaf – RrHDH – Rhodococcus rhodochrous
    
  • 2v9z, 4wcv – RrHDH (mutant)
    
  • 1cv2 – SpHDH – Sphingomonas paucimobilis
    
  • 4h77 – SphHDH – Sphignobium
    
  • 4h7d, 4h7k – SphHDH (mutant)
    
  • 2xt0 – HDH – Plesiocystis pacifica
    
  • 3wi7 – AtHDH – Agrobacterium tumefaciens
    
  • 3wib – AtHHDH (mutant)
    
• Haloalkane dehalogenase complex with halide ion
  • 1edb, 1edd, 2eda, 2edc, 2dhe, 1b6g – XaHDH + halide
    
  • 1cij – XaHDH (mutant) + Br
    
  • 1d07, 1iz7, 1k5p, 1mj5 – SpHDH + halide
    
  • 3fbw, 1cqw, 4hzg – RrHDH + halide
    
  • 3a2m, 3a2n, 3afi – BjHDH + Cl – Bradyrhizobium japonicum
    
  • 3a2l – BjHDH (mutant) + Cl
    
  • 4k2a – HDH + Cl – Bradyrhizobium elkanii
    
  • 3rk4, 3sk0, 4f5z, 4f60 – RrHDH (mutant) + halide
    
  • 4h7e, 4h7f, 4h7h, 4h7i, 4h7j 4h7k – SphHDH (mutant) + halide
    
  • 4brz – RhHDH + Cl - Rhodobacteraceae
    
  • 4mj3 – HDH + Cl – Mycobacterium rhodesiae
    
• Haloalkane dehalogenase other complexes
  • 2dhc – XaHDH + ethylene dichloride
    
  • 2dhd – XaHDH + amono-chloroethoxy-oxobutanoic acid + Cl
    
  • 1g42 – SpHDH + dichloropropane + Cl
    
  • 2bfn – SpHDH + dichloropropanol + Cl
    
  • 1g4h – SpHDH (mutant) + butanol + Cl
    
  • 1g5f – SpHDH + dichloroethane + Cl
    
  • 1iz8 – SpHDH + propanediol + Cl
    
  • 4c6h – RhHDH + hexanol + Cl
    
  • 3fwh, 3g9x, 4e46 – RrHDH + isopropanol + Cl
    
  • 1k6e – SpHDH + bromopropanol + Cl + Br
    
  • 1k63 – SpHDH + bromopropene-1-ol + Cl + Br
    
  • 4fwb – SpHDH (mutant) + trichloropropane + Cl
    
  • 2o2h – MtHDH 3 + dichloroethane + Cl – Mycobacterium tuberculosis
    
  • 2o2i – MtHDH 3 + propanediol + Br
    
  • 2qvb – MtHDH 3 + ethanediol + Cl
    
• Fluoroacetate dehalogenase (FDH)
  • 1y37 – BuFDH – Burkholderia
    
  • 3r3u – RpFDH – Rhodopseudomonas palustris
    
  • 3r40, 3r41 – RpFDH (mutant)
    
• Fluoroacetate dehalogenase complexes
  • 3r3v, 3r3y – RpFDH (mutant) + fluoroacetate
    
  • 3r3w – RpFDH (mutant) + chloroacetate
    
  • 3r3x – RpFDH (mutant) + bromoacetate
    
  • 3r3z – RpFDH + glycolate
    
  • 3b12 – BuFDH (mutant) + fluoroacetate
    
• Halohydrin dehalogenase (HHDH)
  • 1zmo – HHDH – Anthrobacter
    
  • 3zn2 – AtHHDH
    
• Halohydrin dehalogenase complexes
  • 1pwx – AtHHDH + Br
    
  • 1px0 – AtHHDH + haloalcohol mimic
    
  • 1zo8 – AtHHDH + p-nitrostyrene oxide
    
  • 1pwz, 1zmt – AtHHDH + styrene oxide + Cl
    
  • 4ixt – AtHHDH (mutant) + ethyl cyano-hydroxybutyrate
    
  • 4ixw – RrHHDH (mutant) + ethyl oxiranyl acetate – Rhizobium radiobacter
    
  • 4iy1 – RrHHDH + Cl
    
• L-2-haloacid dehalogenase (LHDH)
  • 1jud – PsLHDH – Pseudomonas
    
  • 2w43 – StLHDH – Sulfolobus tokodaii
    
  • 2yml, 2ymm, 2ymp, 2ymq – RhLHDH
    
  • 4ce6, 4cf3, 4cf4, 4cf5, 4cnq – RhLHDH (mutant)
    
  • 3bjx – LHDH – Pseudomonas putida
    
  • 3umc – LHDH – Pseudomonas aeruginosa
    
  • 3um9 – LHDH – Polaromonas
    
  • 3umg – LHDH – Rhodococcus jostii
    
• L-2-haloacid dehalogenase complexes
  • 1aq6, 1qq5 – XaLHDH + formic acid
    
  • 1zrm – PsLHDH (mutant) + butanoic acid
    
  • 1zrn – PsLHDH (mutant) + acetic acid
    
  • 1qh9 – PsLHDH + lactic acid
    
  • 2w11 – StLHDH + lactic acid
    
  • 1qq6, 1qq7 – XaLHDH + aspartate carboxymethyl ester + Cl
    
  • 2yn4 – RhLHDH + chlorobutyrate
    
• DL-2-haloacid dehalogenase (DLHDH)
  • 4n2x – MeDLHDH – Methylobacterium
    
  • 3wj8 – MeDLHDH + bromo-methylpropionate
    
• S-2-haloacid dehalogenase (SHDH)
  • 2no4 – BcSHDH IVA – Burkholderia cepacia
    
  • 2no5 – BcSHDH IVA + 2-monochloroprapanate
    
• Iodotyrosine dehalogenase (ITDH)
  • 3gb5 – mITDH – mouse
    
  • 3to0 – mITDH (mutant)
    
  • 3gfd – mITDH + iodotyrosine
    
  • 3tnz – mITDH (mutant) + iodotyrosine
    
  • 3gh8 – mITDH + diiodotyrosine
    
  • 4ttb – hITDH 1 + FMN
    
  • 4ttc – hITDH 1 + FMN + iodotyrosine
    
• cis-3-chloroacrylic acid dehalogenase (CaaD)
  • 2flz, 3mf8 – CbCaaD – Coryneform bacterium
    
  • 3mf7 – CbCaaD + oxirane-carboxylate
    
  • 2flt – CbCaaD + lactic acid
    
• trans-3-chloroacrylic acid dehalogenase (TaaD)
  • 3ej3 – PpTaaD α+β subunits – Pseudomonas pavonacea
    
  • 3ej7, 3ej9 – PpTaaD α (mutant) +β subunits
    
  • 1s0y – PpTaaD α+β subunits + malonic acid
    
• 5-chloromuconolactone dehalogenase (ClcF)
  • 3znu, 3znj, 4fpi – RoClcF – Rhodococcus opacus
    
  • 3zo7 – RoClcF + 5-chloromuconolactone
    
• 4-chlorobenzoyl CoA dehalogenase (CBCD)
  • 1nzy – PsCBCD
    
  • 1jxz – PsCBCD + hydroxybenzoyl CoA
    
• Tetrachloroethene reductive dehalogenase (TCRD)
  • 4uqu, 4ur3 – SmTCRD catalytic subunit – Sulfurospirillum multivorans
    
  • 4ur0 – SmTCRD catalytic subunit + trichloroethene
    
  • 4ur1 – SmTCRD catalytic subunit + tribromoethene
    
  • 4ur2 – SmTCRD catalytic subunit + iodide
    

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