Antibody 3D structures

3D Structures of Immunoglobulin

Updated on 17-February-2016

Humanized mouse antibody (hmFab) is a modified mFab which resembles more hFab.

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• Fab
  • 7fab, 1mco, 3na9, 3lrs, 3mme, 3hi5, 1vge, 3nfs, 1ad0, 3w9d, 4nm4, 8fab, 1opg, 4fnl, 4fqh, 1om3, 1aqk, 2hff, 2agj, 3hc0, 3g6a, 3dgg, 3dif, 1b2w, 3eyo, 3eyq, 2aj3, 3fzu, 3aaz, 3gje - hFab - human
    
  • 3naa, 3nab, 3nac, 3ncj, 3o2v, 3hc3, 3hc4 - hFab (mutant)
    
  • 3i75, 1nqb, 1f4w, 1aif, 1ghf, 2z91, 1ind, 3bkc, 3bkm, 1iy0, 3pp3, 3pp4, 3okm, 6fab, 2hkh]], 1ay1, 1nbv, 1qbm, 1bbd, 1dsf, 1gpo, 1mnu, 1igf, 1for, 1k6q, 1bz7, 1dqd, 2ipt, 2iq9, 2iqa, 2w60, 2w9d, 3iu4, 1q9k, 1q9l, 1q9o, 2z4q, 1cl7, 1n4x, 1cr9, 1r24, 1gig, 1uyw, 1cgs, 2cgr, 1q0x, 1ibg, 3eo0, 2op4, 2q76, 2ojz, 2g60, 2dbl, 1dbj, 1dbk, 1dbm, 1dba, 1mrc, 2gcy, 1flr, 1uz6, 1rfd, 1t2q, 1ggb, 1ggc, 1bm3, 2eh7, 2fat, 3cfc, 1fl3, 3cfe, 4j1u, 4gq9, 3qg7, 3rvt, 3s62, 4gay - mFab – mouse
    
  • 3eot, 2d03, 3esv, 3et9 – mFab (mutant)
    
  • 3iy2, 3iy3, 3iy4, 3iy5, 3iy6, 3iy7 - mFab – Cryo EM
    
  • 1jpt, 3mxv, 2o5x, 1ucb, 1bbj, 1t04, 2fgw, 1fvd, 1fve - hmFab
    
  • 1cqk – mFab MAK33 CH3 domain
    
  • 3mj8, 3r06 – AhFab – Armenian hamster
    
  • 3iy1, 1zan – rFab – rat
    
  • 4k3e, 4k3d – bFab – bovine
    
  • 4b41, 1shm, 2xa3 – LgFab – Lama glama
    
  • 1f2x – cFab – camel
    
• Anti-HIV Fab
  • 1rz7, 1rz8, 1rzf, 1rzg, 1rzi, 3mlj, 3mug, 3juy, 3qeh, 3ttn, rpi, 3tnm, 4fz8, 4f58, 4f57, 4f5a - hFab
    
  • 3nz8, 3o6k, 3ntc, 3qeg – mFab
    
• Fab: small molecule complex
  • 3o2w - hFab 1e9 (mutant) + transition state analog
    
  • 3ra7 – mFab + digoxigenin – mouse
    
  • 3okd, 3oke, 3okk, 3okl, 3okn, 3oko, 3hzk, 3hzm, 3hzv, 3hzy, 3pho, 3phq, 3hns, 3hnt, 3hnv - mFab + liposaccharide
    
  • 3oau – hFab 2g12 (mutant) + mannose
    
  • 1ikf – hFab R45 + cyclosporin
    
  • 3oay, 3oaz, 3ob0, 1zls, 1zlu, 1zlv, 1zlw - hFab 2g12 + glycan
    
  • 2jb5, 2jb6 - hFab/mFab + hapten
    
  • 1ine, 1ub5, 1ub6 - mFab + hapten
    
  • 3ls4 – mFab + tetrahydrocannabinol
    
  • 1mfc, 1mfd, 1mfe, 4hgw – mFab + polysaccharide
    
  • 1op3, 1op5 - hFab + polysaccharide
    
  • 3eyv - hFab/mFab 13G5 (mutant) + hapten
    
  • 2ntf - mFab RS2-1G9 + lactone analog
    
  • 1riu, 1riv, 1qyg, 1q72 - mFab + cocaine derivative
    
  • 1ynk, 1ynl, 1etz – mFab + sweetener
    
  • 1yef – mFab D2.3 + substrate analog
    
  • 1yeg - mFab D2.3 + product
    
  • 1p7k – mFab + HEPES
    
  • 1q0y – mFab 9B1 + morphine
    
  • 1q9q, 1q9r, 1q9t, 1q9v, 1q9w, 1f4x, 1f4y, 1mfa, 1mfb - mFab + carbohydrate
    
  • 1mex – mFab 29G12 + benzoic acid derivative
    
  • 1mrd, 1mre, 1mrf – mFab JEL103 + nucleotide
    
  • 1dbb – mFab DB3 + progesterone
    
  • 1igj - mFab 26-10 + digoxin
    
  • 4fab – mFab 4-4-20 + fluorescin
    
  • 1dl7 - mFab MCPC603 + phosphocholine
    
  • 3cfb, 3cfd, 2g2r – mFab + stilbene hapten
    
  • 1i3u, 1i3v - LgFab + hapten
    
• Fab: peptide complex
  • 3e8u - mFab + BNP peptide
    
  • 2a6d, 2a6i, 2a6j, 2a6k - mFab + peptide
    
  • 3hr5 – mFab + M1prime peptide
    
  • 3eys, 3eyu - mFab + amyloid-β-related peptide
    
  • 3ggw – mFab + carbohydrate-mimetic peptide
    
  • 3cxd, 3dsf – mFab + osteopontin peptide
    
  • 2zpk – mFab + proteinase-activated receptor peptide
    
  • 3ifl, 3ifn, 3ifo, 3ifp - mFab + amyloid peptide
    
  • 3h0t - hFab + hepcidin peptide
    
  • 1sm3 - hFab SM3 + peptide
    
  • 3eyf – hFab + cytomegalovirus peptide
    
  • 2hfg, 2h9g – hFab + TNF receptor peptide
    
  • 3csy - hFab + Ebola envelope glycoprotein peptide
    
  • 2eh8 - mFab + PRES1 peptide
    
  • 2brr – mFab + outer membrane protein peptide
    
  • 1xgy – mFab + rhodopsin peptide
    
  • 1pz5 – mFab SYA/J6 + peptide
    
  • 1a3r – mFab + rhinovirus capsid peptide
    
  • 1cu4 - mFab + prion protein peptide
    
  • 1fpt – mFab + poliovirus peptide
    
  • 1jp5 – mFab + HIV-1 protease peptide
    
  • 1mvu – mFab + glycoprotein
    
  • 2ap2 – mFab + glycoprotein peptide + C-myc peptide
    
  • 2hh0 – hFab/mFab + prion protein peptide
    
  • 1frg, 1him, 1hin, 1ifh - mFab + hemagglutinin peptide
    
  • 1tet – mFab + cholera toxin peptide
    
  • 1i8i, 1i8k – mFab + EGFR peptide
    
  • 1i8k – mFab + EGFR peptide
    
  • 1i8i, 1i8k – mFab + EGFR peptide
    
  • 1i8k – mFab + EGFR peptide
    
  • 4gag, 4gaj – mFab + genome polyprotein peptide
    
  • 3bky – hFab/mFab + CD20 peptide
    
  • 4hs8 – hFab + hepatitis virus peptide
    
• Anti-HIV Fab: peptide complex
  • 3egs, 3drt, 3drq, 3dro, 2fx7, 2fx8, 2fx9, 2cmr, 1tzg, 1tjg, 3mnw, 3moa, 3mob, 3mod, 1tjh, 1tji, 1u8h, 1u8i, 1u8j, 1u8k, 1u8l, 1u8m, 1u8n, 1u8o, 1u8p, 1u8q, 1u91, 1u92, 1u93, 1u95, 2f5b - hFab anti-HIV + gp41 peptide
    
  • 3ghb, 3ghe, 3c2a - hFab anti-HIV + envelope glycoprotein peptide
    
  • 3go1 - hFab anti-HIV + envelope glycoprotein gp160 peptide
    
  • 3fn0, 2oqj - hFab + peptide
    
  • 2b0s, 2b1a, 2b1h, 3se8, 3se9, 4jkp, 4jpv, 4jb9 - hFab anti-HIV + glycoprotein gp120 peptide
    
  • 1nak, 2f58, 3f58, 1f58, 1acy, 1qnz - mFab anti-HIV + glycoprotein gp120 peptide
    
  • 1ai1, 1ggi – mFab anti-HIV + V3 peptide
    
  • 3o6l, 3o6m - mFab 11H6H1 anti-HIV + Tat peptide
    
  • 1svz - mFab anti-HIV + HIV-2 protease peptide
    
• Fab: protein complex
  • 3raj – mFab HB7 + CD38
    
  • 3o0r – mFab + nitric oxide reductase
    
  • 3mac, 3ma9 – hFab 8062 anti-HIV + transmembrane glycoprotein
    
  • 3pnw – hFab + Tudor domain-containing protein 3
    
  • 3h42 - hFab LDLR + proprotein convertase subtilisin/kexin
    
  • 3nh7 – hFab ABD1556 + bone morphogenetic protein receptor
    
  • 3hi6 – hFab AL-57 + integrin
    
  • 2vxs - hFab + interleukin
    
  • 3b2u, 3b2v – hFab IMC-11F8 + EGFR
    
  • 2r0k, 2r0l – hFab + HGFA
    
  • 3ld8, 3ldb – AhFab + bifunctional arginine demethylase
    
  • 3be1, 3n85, 1n8z - hFab + ERBB-2
    
  • 3kr3 – hFab + IGF-II
    
  • 3g6d – hFab CNTO607 + IL-13
    
  • 3idx, 3idy, 2ny7, 4jpw, 4lsp, 4lsq, 4lsr, 4lss, 4lst, 4lsu, 4lsv - hFab + gp120 core
    
  • 2x7l – Fab anti-HIV + HIV REV
    
  • 3gbm, 3gbn, 3lzf, 3fku, 3sdy, 3ztj, 3ztn, 4fp8, 4fqi, 4fqj, 4fqk, 4fql, 4fqr, 4fqv, 4fqy, 4gxu, 4nm8- hFab + hemagglutinin
    
  • 3g6j – hFab + complement C3
    
  • 1fsk - mFab + pollen allergen
    
  • 2wub, 3k2u – hFab 40 + hepatocyte growth factor activator
    
  • 3grw - hFab + fibroblast growth factor receptor
    
  • 3bdy, 2qr0, 2fjg, 2fjh, 1cz8 – hFab + VEGF
    
  • 1tzh, 1tzi - mFab + VEGF
    
  • 3bqu – hFab 2F5 anti-HIV + mFab 3H6
    
  • 1adq – hFab IGM + igG1 Fc
    
  • 3dvg, 3dvn – hFab igG1 + ubiquitin
    
  • 3bn9 – hFab E2 + membrane-type serine protease
    
  • 2jix – hFab ABT-007 + erythropoietin receptor
    
  • 1za3 - hFab YSD1 + TNF receptor
    
  • 3l95 – hFab + NRR1
    
  • 1uj3, 4dtg – hFab + tissue factor
    
  • 3lev – hFab 2F5 + RNA polymerase sigma factor
    
  • 3ru8 – hFab B12 + epitope scaffold 2BODX43
    
  • 3skj – hFab + ephrin receptor
    
  • 3sob – hFab + LPR6
    
  • 3vg9 – hFab + adenosine receptor
    
  • 3vga – hFab + adenosine receptor (mutant)
    
  • 2qqk, 2qql, 2qqn – hFab + neuropilin
    
  • 2vyr – hFab + MDM4
    
  • 4c2i – hFab + dengue virus envelope protein
    
  • 4dag – hFab + metapneumovirus glycoprotein F0
    
  • 1jps - hmFab D3H44 + tissue factor
    
  • 1ahw - mFab 5G9+ tissue factor
    
  • 1eo8, 1ken, 4mhh, 4mhj - mFab + hemagglutinin
    
  • 2w9e, 1tpx, 1tqb, 1tqc – mFAB + major prion protein
    
  • 2oz4 – mFab + intercellular adhesion molecule
    
  • 3eo1 - mFab GC-1008 + transforming growth factor β-3
    
  • 2dtg – mFab 83 + insulin receptor
    
  • 1egj – mFab + cytokine receptor
    
  • 2bdn – mFab + cytokine A2
    
  • 1jrh – mFab + interferon-γ receptor
    
  • 1ob1 – mFab + major merozoite surface protein
    
  • 1qfw – mFab + gonadotropin
    
  • 4cad – mFab + RCE1
    
  • 4m48 – mFab + dopamine transporter
    
  • 1yjd – mFab 5.11A1 + CD28
    
  • 1sy6 – mFab OKT3 + CD3
    
  • 4k4m, 4k2u – mFab + erythrocyte binding antigen
    
  • 1afv – mFab anti-HIV + capsid protein C
    
  • 2b2x – rFab AQC2 + integrin
    
  • 2r56 – bFab igE + β-lactoglobulin
    
  • 1bzq, 2p42, 2p43, 2p44, 2p45, 2p46, 2p47, 2p48, 2p49, 2p4a – bFab Cab-Rn05 + RNase
    
  • 2r9h – mFab + exchange transporter ClCA
    
  • 1nca, 1ncb, 1ncc, 1ncd – mFab + neuraminidase
    
  • 1rjl – mFab + outer surface protein
    
  • 1mhh – mFab + protein L (mutant)
    
  • 1pg7 – mFab 6A6 + hmFab D3H44
    
  • 1pkq – hFab/mFab 8-18C5 + myelin glycoprotein
    
  • 2jel – mFab JEL42 + histidine-containing protein
    
  • 1nsn – mFab N10 + nuclease
    
  • 1rvf – mFab 17-IA + intact rhinovirus
    
  • 3j3o, 3j3p- mFab + poliovirus proteins – cryoEM
    
  • 1nfd – mFab H57 + T-cell receptor
    
  • 1igc – mFab MOPC21 + streptococcal protein G
    
  • 1iai – mFab idiotipic + mFab anti-idiotypic
    
  • 2r8s – mFab + RNA
    
  • 2fr4, 1xf2, 1xf3, 1xf4, 1i8m, 1cbv – mFab + DNA
    
  • 1mhp, 3q3g, 3qa3 – mFab + integrin
    
  • 3ab0 – mFab + BCLA protein
    
  • 3etb – mFab M18 (mutant) + anthrax-protective antigen
    
  • 3f5w, 3pjs, 3efd, 3eff, 2hjf, 2w0f, 4msw – mFab + KcsA K+ channel
    
  • 3stl, 3stz, 4i9w - mFab + KcsA K+ channel (mutant)
    
  • 1kb5 – mFab + T-cell receptor
    
  • 4i18 – mFab + pro-lactin receptor
    
  • 1uwx – mFab + protein G prime
    
  • 4ckd – mFab + β-galactosidase
    
  • 3fmg – mFab + glycoprotein VP7
    
  • 3ve0 - mFab + Ebola envelope glycoprotein
    
  • 3k7u, 3k80 – LgFab + MP18 RNA editing protein – Lama glama
    
  • 3mj9 – AhFab HL4E10 + JAML
    
  • 3r08 - AhFab 2C11 + CD3ε
    
  • 4hti – rFab + TNF ligand
    
  • 1g6v – bFab + carbonic anhydrase
    
  • 4hgk – Fab + albumin – shark
    
  • 4ej1, 4eiz, 4eig – LgFab + DHFR
    
  • 3k81, 3stb, 4dk3, 4dk6, 4dka – LgFab + RNA editing complex protein
    
  • 3p0g, 4lde, 4ldl, 4ldo – LgFab + adrenergic receptor
    
  • 1jto, 1jtp, 1jtt, 1ri8, 1xfp, 1zmy, 1zv5, 1zvh – cFab + lysozyme
    
  • 2x89 – cFab + β-2-microglobulin
    
  • 4i0c – cFab + lysozyme
    
  • 4ht1 – Fab + TNF ligand 12 – rabbit
    
• Fab: protein ternary complex
  • 3ixx, 3ixy - mFab E53 + envelope glycoprotein + West Nile virus peptide
    
  • 1g9m, 1g9n, 1gc1, 2i5y, 2i60, 2nxy, 2nxz, 2ny0, 2ny1, 2ny2, 2ny3, 2ny4, 2ny5, 2ny6, 3jwd, 3jwo - hFab + envelope glycoprotein gp120 + CD4
    
  • 2wuc - hFab 40 + hepatocyte growth factor activator + inhibitor
    
  • 3lqa, 2qad - hFab anti-HIV + CD4 + gp160
    
  • 3d85 - hFab 7G10 + IL-12 + IL-23
    
  • 3bt2 – hFab anti-UPAR + urokinase-type plasminogen activator + vitronectin
    
  • 3gjf, 3hae – hFab + β-2-microglobulin + MHC antigen + NYESO peptide
    
  • 3gb7, 2p7t, 2h8p, 2hfe, 2atk - mFab + KcsA K+ channel + ion
    
  • 3or6, 3or7, 3ogc, 3fb7, 3f7v, 3f7y, 3fb5, 3fb6, 3fb8, 3iga, 2itc, 2itd, 2nlj, 2bob, 2boc, 1s5h, 1r3i, 1r3j, 1r3k, 1r3l, 1k4c, 1k4d, 3hpl - mFab + KcsA K+ channel (mutant) + ion
    
  • 2fd6 – mFab ATN-615 + urokinase-type plasminogen activator + urokinase plasminogen receptor
    
  • 1j5o – mFab + reverse transcriptase + DNA
    
  • 1qkz – mFab + protein G prime + major outer membrane protein peptide
    
  • 2ibz – mFab + cytochrome bc1 complex + stigmatellin
    
  • 3v0a – LgFab + BONT/A1 + NTNH
    
  • 3sn6 – LgFab + adrenergic receptor + guanine nucleotide-binding protein
    
  • 4laj - LgFab + envelope glycoprotein gp120 + CD4
    
• Full Immunoglobulin
  • 1hzh - hFab IgG B12
    
  • 1iga - hIgA1 - model
    
• Fc Fragments
  • 3dnk - hFc Igg1br />
  • 1qp1 – hFc BRE
    
  • 3muh – hFc PG9
    
  • 4bsv, 4bsw – hFc heterodimeric (mutant)
    
  • 1f6a - hFc IgE + high-affinity receptor Fc (ε) RI (α)
    
  • 1fp5 - hFc IgE C ε 3-C ε 4
    
• Fv Fragments
  • 3dur, 3dus, 3duu, 3dv4, 3dv6 – mFv + Ig-like protein
    
  • 3h3b – mFv + ERBB2
    
  • 3hb3 – mFv + cytochrome c oxidase subunit 1-β
    
  • 1qle - mFv + cytochrome c oxidase
    
  • 3ln9 – cFv B10
    
  • 3tpk – cFv KW1
    
  • 3zhd, 3zhk, 3zhl – hFv scaffold
    
  • 1kxq – cFv + α-amylase
    
  • 1mel, 1rjc, 1zvy – cFv + lysozyme
    

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Michal Harel, Joel L. Sussman, Jaime Prilusky