4hkf | pdb_00004hkf

Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA

spinqualitylabelsall models 4hkf, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4hkf is a 1 chain structure with sequence from Brachidanio rerio. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ACO, SO4 NonStd Res: MSE Gene: atat1, mec17, si:ch211-152p11.5, zgc:65893 (Brachidanio rerio) Activity: Alpha-tubulin N-acetyltransferase, with EC number 2.3.1.108 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [ATAT_DANRE] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May promote directional cell locomotion and chemotaxis (By similarity). May be required for normal sperm flagellar function (By similarity). May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development. Acetylates alpha-tubulin in neurons, but not in cilia.[HAMAP-Rule:MF_03130] See Also Alpha-tubulin N-acetyltransferase

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