| Function
Rhomboid protease is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain[1]. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected by from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins.
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3D Structures of rhomboid protease
Updated on 10-August-2016
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- Rhomboid protease
- 2ic8, 2irv, 2nrf, 2o7l, 3b45, 2xov, 4njn, 4njp – EcGlpG core region – Escherichia coli
- 2xtu, 3b44, 2xtv – EcGlpG core region (mutant)
- 4hdd – EcGlpG N terminal
- 2lep, 2mja – EcGlpG N terminal - NMR
- 3odj – HiGlpG - Haemophilus influenzae
- 2nr9 – HiGlpG (mutant) + detergent
- 2gqc – RP N terminal – NMR – Pseudomonas aeruginosa
- Rhomboid protease complex with inhibitor
- 2xow, 3zeb – EcGlpG core region + isocoumarin inhibitor
- 3txt, 4h1d – EcGlpG core region + DFP inhibitor
- 3ubb – EcGlpG core region + phosphonofluoridate inhibitor
- 3zmh, 3zmi, 3zmj, 3zot – EcGlpG core region + β-lactam inhibitor
- 4qnz – EcGlpG core region (mutant) + peptide inhibitor
- 4qo0, 4qo2 – EcGlpG core region + peptide inhibitor
References
