Talin

Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomain interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3.

3D Structures of Talin

Updated on 06-September-2016

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• Talin subdomains
  • 2x0c, 2kbb, 3dyj, 1sj7, 1sj8 – mTal rod – mouse
    
  • 2kma – mTal F0F1 – NMR
    
  • 2kc1 - mTal F0 – NMR
    
  • 2kc2 - mTal F1 – NMR
    
  • 2hrj - cTal F2 – NMR
    
  • 1mix – cTal F2F3
    
  • 4f7g - mTal F2F3 + rod segment domain
    
  • 2kgx – mTal F3+mTal fragment – NMR
    
  • 3ivf – mTal FERM domain
    
  • 2l7n – mTal B – NMR
    
  • 2l10 – mTal C - NMR
    
  • 2lqg - mTal R4 helix – NMR
    
  • 4w8p - mTal R7-8 + RIAM
    
  • 2mwn – hTal1 + RIAM – human - NMR
    
• Talin integrin-binding sites
  • 2jsw, 2qdq – mTal IBS – NMR
    
  • 3g9w – mTal2 F2F3+integrin tail
    
  • 1miz, 1mk7, 1mk9 - hTal+integrin tail
    
  • 2h7d, 2h7e - cTal FERM F3+integrlin fragment – NMR
    
  • 3fyq – Tal rod IBS2 – Drosophila melanogaster
• Talin vinculin-binding sites
  • 2kvp, 2b0h – mTal VBS3 – NMR
    
  • 1xwj, 1zvz, 1zw2, 1zw3 - cTal VBS3+ vinculin head – chicken
    
  • 1u6h - cTal VBS2+ vinculin head
    
  • 1t01 - cTal VBS1+ vinculin head
    
  • 1syq - hTal VBS1+ vinculin head
    
  • 1rkc, 3s90 - hTal VBS3+ vinculin head
    
  • 1u89, 2l7a - mTal VBS2 – NMR
    
  • 4dj9 – hTal VBS50 + vinculin head
• Talin phosphatidylinositol phosphate kinase binding sites
  • 1y19 - mTal F2F3+ PIP kinase C-terminal
    
  • 2g35 - mTal F3+PIP kinase peptide – NMR
• Talin layilin-binding sites
  • 2k00 - cTal F3+layilin fragment – NMR

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Joel L. Sussman, Michal Harel