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Function
Trehalulose synthase (THS) converts sucrose to trehalulose (TH)[1].
Relevance
Since TH is a sugar substitute and is absorbed more slowly than sucrose it can be used in diabetic and sports food and drinks.
Structural highlights
THS binds sucrose in a deep pocket with mostly conserved residues[2].
- ↑ Thevelein JM, Hohmann S. Trehalose synthase: guard to the gate of glycolysis in yeast? Trends Biochem Sci. 1995 Jan;20(1):3-10. PMID:7878741
- ↑ Ravaud S, Robert X, Watzlawick H, Haser R, Mattes R, Aghajari N. Trehalulose synthase native and carbohydrate complexed structures provide insights into sucrose isomerization. J Biol Chem. 2007 Sep 21;282(38):28126-36. Epub 2007 Jun 27. PMID:17597061 doi:10.1074/jbc.M704515200
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3D structures of trehalulose synthase
Updated on 22-September-2016
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- Trehalulose synthase
- Trehalulose synthase complex
- 2pwd, 2pwg – PmTHS + inhibitor
- 2pwe – PmTHS (mutant) + sucrose
- 2pwf – PmTHS (mutant) + glucose
- 4gi6, 4h7v – RhTHS (mutant) + glucose
- 4gi8 – RhTHS (mutant) + sucrose
- 4h8v – RhTHS + TH
- 4gi9 – RhTHS (mutant) + TH
- 4h8u – RhTHS (mutant) + sucrose + TH
- 4gia, 4ha1 – RhTHS (mutant) + isomaltulose
- 4gin – RhTHS (mutant) + inhibitor
References
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