Siderocalin

spinqualitylabelsall models Human siderocalin complex with the siderophore carboxymycobactin (PDB code 1x89) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Siderocalin (Scn) binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence. Relevance Scn-NGAL levels are markedly upregulated by tissue damage. Scn-NGAL is derived from damaged kidneys. The presence of Scn-NGAL in serum or urine anticipates a severe course for the patient including the need for dialysis and the possibility of death. Structural highlights Scn-NGAL interacts with the siderophore carboxymycobactin where the latter is centered in the protein calyx making multiple interactions including cation-π bonds involving several lysines and arginine.

3D structures of siderocalin

Updated on 25-December-2016

{"openlevels":0}

• Siderocalin or lipocalin-2
  • 5jr8, 3bx8 – hScn NGAL - human
    
  • 3s26 – mScn NGAL - mouse
    
  • 2kt4 – qScn Q83 – quail
    
• Siderocalin complex
  • 4mvi, 4mvk, 4mvl – hScn NGAL (mutant) + beta amyloid protein 40 peptide
    
  • 3bx7 – hScn NGAL + CTLA-4
    
  • 3tzs – hScn NGAL (mutant) + phenylurea
    
  • 4zfx, 4zhc, 4zhd, 4zhf, 4zhg, 4zhh, 4qae, 4k19, 4aiw, 4aix, 3u03, 3u0d, 3k3l, 3dsz, 1x89, 1x8u, 1x71 – hScn NGAL + siderophore
    
  • 3tf6, 3t1d, 3i0a, 3hwd – hScn NGAL (mutant) + siderophore
    
  • 3pec, 3ped – hScn NGAL + siderophore + Fe
    
  • 3hwe, 3hwf, 3hwg, 3cmp, 3by0, 3cbc – hScn NGAL (mutant) + siderophore + Fe
    
  • 3fw4, 3fw5 – hScn NGAL (mutant) + catechol + Fe
    
  • 4gh7 – hScn NGAL + fibronectin
    
  • 3u9p – mScn NGAL + Fab
    
  • 2lbv – qScn Q83 + enterobactin – NMR
    
  • 3sao – cScn + myristoyl lysophosphatidic acid - chicken
    

>

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman