Apoptosis-inducing factor

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Apoptosis-inducing factor (AIF) is an intermembrane flavoprotein which induces caspase-independent peripheral chromatin condensation and large-scale DNA fragmentation and thus causes cell death. AIF contains the cofactor FAD. Relevance AIF deficiency is a risk factor for the development of diabetic kidney disease.

3D structures of apoptosis-inducing factor

Updated on 29-December-2016

4bv6, 4lii, 1m6i – hAIF – human
5fmh, 5kvh, 5kvi, 5fs6, 5fs7, 5fs8, 4fdc – hAIF (mutant)
4bur – hAIF + NAD
3gd3, 1gv4 – mAIF – mouse
3gd4 – mAIF + NAD

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Michal Harel, Alexander Berchansky, Joel L. Sussman