Borealin

spinqualitylabelsall models Human borealin N-terminal (green) complex with survivin (deepskyblue), INCENP N-terminal (pink), MES and Zn+2 ion (grey) (PDB code 2qfa) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Borealin (BOR) is a member of the chromosomal passenger complex (CPC) which includes survivin and INCENP. It is required for the stability of the bipolar mitotic spindle. Relevance Borealin plays a key role in liver development, regeneration and tumorigenesis and may be a potential target for related liver diseases. Structural highlights The interactions between BOR, survivin and INCENP involve a set of hydrophobic interactions formed by the three-helix bundle and links by electrostatic interactions.

3D structures of borealin

Updated on 16-January-2017

survivin, INCENP – hBOR N-terminal + survivin – human
2qfa – hBOR N-terminal + survivin + INCENP
2kdd – hBOR C-terminal – NMR

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Michal Harel, Alexander Berchansky, Joel L. Sussman