Nonstructural protein

spinqualitylabelsall models Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry 1nhu) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Nonstructural protein (NS) is a protein encoded by a virus which is not part of the viral particle. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro). For homology model and multiple sequence alignment see User:Michael Strong/H1N1/NS User:Michael Strong/H1N1/NS1/MSA User:Michael Strong/H1N1/NS2/MSA Student Project 4 for UMass Chemistry 423 Spring 2015. Structural highlights Hepatitis virus NS active site shows hydrogen bond interactions and hydrophobic pocket interactions.

3D Structures of Nonstructural protein

Updated on 27-August-2017

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• Nonstructural protein
  • 3o9q, 4opa, 4oph – IvNS1 (mutant) – Influenza virus
    
  • Student Project 4 for UMass Chemistry 423 Spring 2015, 3o9s, 3o9t, 3o9u, 3f5t – IvNS1
    
  • 3m8a, 2z0a, 1xeq, 1ail – IvNS1 RNA-binding domain
    
  • 3p31 – IvNS1 C terminal effector domain
    
  • 3p38, 3p39 – IvNS1 C terminal effector domain (mutant)
    
  • 1ns1 - IvNS1 RNA-binding domain - NMR
    
  • 3m5r, 2gx9 - IvNS1 effector domain
    
  • 1pd3 – IvNS2 M1-binding domain
    
  • 3l6p, 3lkw – DvNS2B/3 protease domain (mutant) – Dengue virus
    
  • 4r05 – DvNS5 residues 2491-2752
    
  • 2o1j – RvNSP4 diarrhea-inducing domain – Rotavirus
    
  • 2gu0 – RvNS2
    
  • 2ajj, 2ajm, 2ajn, 2ajo – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR
    
  • 1fw5 – NSP1 membrane-binding domain – Semliki forest virus – NMR
    
  • 5vj2 – NS1 – respiratory syncytial virus
    
  • 5i65 – NS ORF1A – porcine reproductive and respiratory syndrome virus
    
  • 1qol – NSP20A (mutant) - Foot-and-mouth disease virus
    
  • 1nhu – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus
    
  • 1r7c, 1r7d, 1r7e, 1r7f, 1r7g - HvNS5A membrane-anchor domain - NMR
    
  • 2gdt, 2hsx – SvNS1 (mutant) – Sars coronavirus – NMR
    
  • 2jzd, 2jze, 2jzf, 2rnk – SvNS3 residues 527-651 – NMR
    
  • 2kaf - SvNS3 residues 1473-1532 – NMR
    
  • 2kys – SvNS7 – NMR
    
  • 2l8k – NS7 residues 1454-1575 – NMR
    
  • 3mtv – NS1 residues 181-383 – PRRS virus
    
  • 3zfn, 3zfo, 3zfq, 3zfp, 3zfr, 3zft, 3zfu – Npro (mutant) – Pestivirus
    
  • 4x2z – NS3 residues 1174-1483 – Avian infectious bronchitis virus
    
• Nonstructural protein binary complex
  • 2xbm – DvNS5 methyltransferase domain + RNA
    
  • 3p8z - DvNS5 methyltransferase domain + SAH + inhibitor
    
  • 5cuq - DvNS5 methyltransferase domain + inhibitor
    
  • 5fc8 - DvNS5 C-terminal + importin
    
  • 2hye – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5
    
  • 2b5l - SvNSV + DNA damage-binding protein
    
  • 1nhv, 1nhu – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor
    
  • 1dxp, 1dy8, 1dy9, 1w3c – HvNS4A + HvHelicase NS3
    
  • 4k8b - HvNS4A + HvProtease NS3 + inhibitor
    
  • 4a1t, 4a1x - HvNS4A + peptide inhibitor
    
  • 3phe – HvNS5B + quinolone derivative
    
  • 3ub0 – NSP6 + NSP7 – Feline infectious peritonitis virus
    
  • 1knz – RvNSP34 N terminal + mRNA
    
  • 1lj2 – RvNSP34 C terminal + eukaryotic protein synthesis initiation factor peptide
    
  • 4r8r – DvNS5 residues 2491-2752 + adenosyl-Met
    
  • 4r8s – DvNS5 residues 2491-2752 + sinefungin
    

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Alexander Berchansky, Michal Harel