Sphingomyelinase

Function

Sphingomyelinase (SMase) or sphingomyelin phosphodiesterase is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide. The SMase is classified into 5 types according to their pH dependence and cation dependence.

Disease

Mutations in acid SMase are found in patients with Niemann-Pick disease.

3D structures of sphingomyelinase

Updated on 03-September-2017

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• SMase
  • 3rlh, 3rlg – SMase D (mutant) – Loxosceles intermedia
    
  • 1xx1, 2f9r – SMase I – Loxosceles laeta
    
  • 1zwx – SMase C – Listeria ivanovii
    
  • 2ddr, 2dds, 2ddt – BcSMase + cation – Bacillus cereus
    
  • 2uyr – BcSMase (mutant)
    
  • 3wcx – SMase C – Streptomyces griseocarneus
    
• Acid SMase
  • 5fib – mSMase – mouse
    
  • 5hqn – mSMase catalytic domain
    
  • 5fi9 – mSMase + inhibitor
    
  • 5fic – mSMase + lipid
    
  • 5jg8 – hSMase – human
    

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