Siderocalin

spinqualitylabelsall models Human siderocalin complex with the siderophore carboxymycobactin (PDB code 1x89) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Siderocalin (Scn) or neutrophil gelatinase-associated lipocalin binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence. Relevance Scn-NGAL levels are markedly upregulated by tissue damage. Scn-NGAL is derived from damaged kidneys. The presence of Scn-NGAL in serum or urine anticipates a severe course for the patient including the need for dialysis and the possibility of death. Structural highlights Scn-NGAL interacts with the siderophore carboxymycobactin where the latter is centered in the protein calyx making multiple interactions including cation-π bonds involving several lysines and arginine.

3D structures of siderocalin

Updated on 03-October-2017

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• Siderocalin or lipocalin-2
  • 5jr8, 3bx8, 5khp, 5kid, 5kic – hScn NGAL - human
    
  • 3s26 – mScn NGAL - mouse
    
  • 2kt4 – qScn Q83 – quail
    
• Siderocalin complex
  • 4mvi, 4mvk, 4mvl – hScn NGAL (mutant) + β-amyloid protein 40 peptide
    
  • 3bx7 – hScn NGAL + CTLA-4
    
  • 3tzs – hScn NGAL (mutant) + phenylurea
    
  • 4zfx, 4zhc, 4zhd, 4zhf, 4zhg, 4zhh, 4qae, 4k19, 4aiw, 4aix, 3u03, 3u0d, 3k3l, 3dsz, 1x89, 1x8u, 1x71 – hScn NGAL + siderophore
    
  • 3tf6, 3t1d, 3i0a, 3hwd – hScn NGAL (mutant) + siderophore
    
  • 3pec, 3ped – hScn NGAL + siderophore + Fe
    
  • 3hwe, 3hwf, 3hwg, 3cmp, 3by0, 3cbc – hScn NGAL (mutant) + siderophore + Fe
    
  • 3fw4, 3fw5 – hScn NGAL (mutant) + catechol + Fe
    
  • 4gh7 – hScn NGAL + fibronectin
    
  • 3u9p – mScn NGAL + Fab
    
  • 2lbv – qScn Q83 + enterobactin – NMR
    
  • 3sao – cScn + myristoyl lysophosphatidic acid - chicken
    

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Michal Harel, Alexander Berchansky, Joel L. Sussman