2rf6 | pdb_00002rf6

Crystal Structure of the Vaccinia Virus Dual-Specificity Phosphatase VH1

Structural highlights

2rf6 is a 1 chain structure with sequence from Vaccinia virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	SO4
Related:	2p4d, 2q05
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DUSP_VACCW] Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein.^[1] ^[2] ^[3] ^[4] ^[5]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Derrien M, Punjabi A, Khanna M, Grubisha O, Traktman P. Tyrosine phosphorylation of A17 during vaccinia virus infection: involvement of the H1 phosphatase and the F10 kinase. J Virol. 1999 Sep;73(9):7287-96. PMID:10438817
↑ Najarro P, Traktman P, Lewis JA. Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation. J Virol. 2001 Apr;75(7):3185-96. PMID:11238845 doi:https://dx.doi.org/10.1128/JVI.75.7.3185-3196.2001
↑ Guan KL, Broyles SS, Dixon JE. A Tyr/Ser protein phosphatase encoded by vaccinia virus. Nature. 1991 Mar 28;350(6316):359-62. PMID:1848923 doi:https://dx.doi.org/10.1038/350359a0
↑ Mann BA, Huang JH, Li P, Chang HC, Slee RB, O'Sullivan A, Anita M, Yeh N, Klemsz MJ, Brutkiewicz RR, Blum JS, Kaplan MH. Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons. J Interferon Cytokine Res. 2008 Jun;28(6):367-80. doi: 10.1089/jir.2007.0113. PMID:18593332 doi:https://dx.doi.org/10.1089/jir.2007.0113
↑ Koksal AC, Cingolani G. Dimerization of Vaccinia virus VH1 is essential for dephosphorylation of STAT1 at tyrosine 701. J Biol Chem. 2011 Apr 22;286(16):14373-82. doi: 10.1074/jbc.M111.226357. Epub, 2011 Mar 1. PMID:21362620 doi:https://dx.doi.org/10.1074/jbc.M111.226357

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OCA

[1] Derrien M, Punjabi A, Khanna M, Grubisha O, Traktman P. Tyrosine phosphorylation of A17 during vaccinia virus infection: involvement of the H1 phosphatase and the F10 kinase. J Virol. 1999 Sep;73(9):7287-96. PMID:10438817

[2] Najarro P, Traktman P, Lewis JA. Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation. J Virol. 2001 Apr;75(7):3185-96. PMID:11238845 doi:https://dx.doi.org/10.1128/JVI.75.7.3185-3196.2001

[3] Guan KL, Broyles SS, Dixon JE. A Tyr/Ser protein phosphatase encoded by vaccinia virus. Nature. 1991 Mar 28;350(6316):359-62. PMID:1848923 doi:https://dx.doi.org/10.1038/350359a0

[4] Mann BA, Huang JH, Li P, Chang HC, Slee RB, O'Sullivan A, Anita M, Yeh N, Klemsz MJ, Brutkiewicz RR, Blum JS, Kaplan MH. Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons. J Interferon Cytokine Res. 2008 Jun;28(6):367-80. doi: 10.1089/jir.2007.0113. PMID:18593332 doi:https://dx.doi.org/10.1089/jir.2007.0113

[5] Koksal AC, Cingolani G. Dimerization of Vaccinia virus VH1 is essential for dephosphorylation of STAT1 at tyrosine 701. J Biol Chem. 2011 Apr 22;286(16):14373-82. doi: 10.1074/jbc.M111.226357. Epub, 2011 Mar 1. PMID:21362620 doi:https://dx.doi.org/10.1074/jbc.M111.226357

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2rf6 | pdb_00002rf6

Crystal Structure of the Vaccinia Virus Dual-Specificity Phosphatase VH1

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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