Chitinase

spinqualitylabelsall models Chitinase A complex with (GlcNac)4 and ethylene glycol (PDB entry 3wh1) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Chitinases cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium (1ctn) and a plant (2hvm). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. Disease Chi is related to allergies and asthma. Structural highlights The chitin tetrasaccharide binding site of Chitinase A.

3D Structures of Chitinase

Updated on 10-April-2018

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• Chitinase I
  • 1ctn, 2hvm – VhChi residues 22-597 – Vibrio harveyi
    
  • 3b9e - VhChi residues 22-597 (mutant)
    
  • 1k85 – BcChi fibronectin domain – Bacillus circulans – NMR
    
  • 1itx - BcChi catalytic domain
    
  • 1ed7 – BcChi chitin-binding domain - NMR
    
  • 1ll6, 1ll7 - CiChi residues 36-427 (mutant) – Coccicioides immitis
    
  • 1d2k - CiChi residues 36-427
    
  • 3n11 – BcChi – Bacillus cereus
    
  • 3iwr, 2dkv – Chi residues 33-340 – Japanese rice
    
  • 3g6l - BoChi residues 21-426 – Bionectria ochroleuca
    
  • 3oa5, 4dws – Chi – Yersinia entomophaga
    
  • 4mpi – HbChi chitin-binding domain – Hevea brasiliensis
    
  • 4mst – HbChi catalytic domain
    
  • 4wjx, 4wka – hChi catalytic domain - human
    
  • 4tx7 – Chi – yard-long bean
    
• Chitinase I binary complex
  • 3arp, 3arq, 3arr, 3ars, 3art, 3aru, 3arv, 3arw, 3arx, 3ary, 3arz – VhChi residues 22-597 + inhibitor
    
  • 3as0, 3as1, 3as2, 3as3 – VhChi residues 22-597 (mutant) + inhibitor
    
  • 3b9a, 3b9d - VhChi residues 22-597 + polysaccharide
    
  • 2xvn, 2xuc – AfChi residues 29-307 + inhibitor – Aspergillus fumigatus
    
  • 3n13, 3n15, 3n17, 3n18 – BcChi (mutant) + NAG
    
  • 3n12 – BcChi + Zn
    
  • 3n1a - BcChi (mutant) + inhibitor
    
  • 3g6m - BoChi residues 21-426 + caffeine
    
  • 1waw, 1wb0, 4wk9, 4wkf, 4wkh – hChi catalytic domain + polypeptide – human
    
  • 1hkk, 1hkm, 3rm4, 3rm8, 3rm9, 3rme – hChi catalytic domain + inhibitor
    
  • 1ll4 - CiChi residues 36-427 + inhibitor
    
  • 3wl1, 3wqv, 3wqw – cbChi + GlcNAC
    
  • 3wl0 – cbChi (mutant) + GlcNAC
    
• Chitinase II
  • 1e15, 3wd0 - SmChi
    
  • 1ogb, 1goi, 1e6p - SmChi (mutant)
    
  • 1kfw – Chi catalytic domain – Arthrobacter
    
  • 1dxj – Chi – Jack bean
    
  • 5y29 – OfChi catalytic domain 1 residues 1606-1992 – Ostrinia furnacalis
    
  • 5y2a – OfChi catalytic domain 2 residues 2056-2438
    
• Chitinase II binary complex
  • 1ogg, 1ur9 - SmChi (mutant) + inhibitor
    
  • 1e6n - SmChi (mutant) + polysaccharide
    
  • 1ur8, 1gpf, 1e6r, 3wd1, 3wd2, 3wd3, 3wd4 - SmChi + inhibitor
    
  • 1e6z – SmChi + intermediate
    
  • 2a3a, 2a3b, 2a3c, 2a3e – AfChi + inhibitor
    
  • 1w1p, 1w1t, 1w1v, 1w1y, 1o6i, 1h0g, 1h0i – SmChi + polypeptide
    
  • 5y2b – OfChi catalytic domain 1 + acetylchitooctaose
    
  • 5y2c – OfChi catalytic domain 2 (mutant) + acetylchitooctaose
    
• Chitinase III
  • 2dbt, 1wvu – SgChi residues 30-294 – Streptomyces griseus
    
  • 1wvv - SgChi residues 30-294 (mutant)
    
  • 2d49 – SgChi chitin-binding domain - NMR
    
  • 2xvp – AfChi
    
  • 2xtk, 4tx6 – AfChi + inhibitor
    
  • 4toq – Chi - pomegrenate
    
  • 5wup – OfChi residues 1-482
    
  • 5wv8 – OfChi residues 1-482 (mutant)
    
  • 5wv9 – OfChi residues 1-482 + GlcNAc
    
  • 5wvb – OfChi residues 1-482 (mutant) + GlcNAc
    
  • 5wus – OfChi residues 528-987
    
  • 5wvf – OfChi residues 528-987 (mutant)
    
  • 5wvh – OfChi residues 528-987 + GlcNAc
    
  • 5wvg – OfChi residues 528-987 (mutant) + GlcNAc
    
• Chitinase IV
  • 3hbd, 3hbe, 3hbh - Chi catalytic domain – Norway spruce
    
  • 4mck – Chi - maize
    
  • 5h7t – Chi chitinase domain – Japanese cedar
    
• Chitinase V
  • 3alf – tChi residues 26-377 – tobacco
    
• Chitinase V binary complex
  • 3alg - tChi residues 26-377 (mutant) + NAG
    
  • 3chc, 3chd, 3che, 3chf - AfChi + polypeptide
    
  • 3ch9, 2iuz – AfChi + inhibitor
    
• Chitinase VIII
  • 2cjl - Chi residues 41-244 – Streptomyces coelicolor
    
• Chitinase XVIII
  • 3sim – Chi – Crocus vernus
• Chitinase A
  • 3wh1, 3wij – BcChiA + GlcNAC – Bryum coronatum
    
  • 4ij4 – BcChiA (mutant) + GlcNAC
    
  • 4mnj, 4r5e – spChiA – sago palm
    
  • 4mnk – spChiA + GlcNAC
    
  • 4mnl, 4mnm – spChiA (mutant) + GlcNAC
    
  • 5dez – ApChiA + NAG – Autographa polyhedrosis
    
  • 5df0 – ApChiA + NAG + chitotriothiazoline
    
  • 5bum – ChiA LYSM domain – field horsetail
    
  • 1edq, 1ctn - SmChiA – Serratia marcescens
    
  • 1x6l, 1rd6 – SmChiA (mutant)
    
  • 1x6n - SmChi (mutant) + inhibitor
    
  • 1ffq, 2wk2, 2wly, 2wlz, [[[2wm0]] - SmChi + inhibitor
    
  • 1nh6, 1k9t, 1ffr, 1eib, 1ehn - SmChi (mutant) + polysaccharide
    
  • 4pxv – PrChiA LYSM domain – Pteris ryukuensis
    
  • 4rl3 – PrChiA catalytic domain
    
• Chitinase B
  • 4z2g, 4z2h, 4z2i, 4z2j, 4z2k, 4z2l – SmChiB + inhibitor
    
• Chitinase C
  • 4dyg – RyChiC + NAG – Rye
    
  • 4dwx - RyChiC
    
  • 4j0l – RyChiC + GlcNAC
    
  • 4axn – SmChiC
    
• Chitinase H
  • 3w4r, 5gpr – cbChiH – corn borer
    
  • 3wkz – cbChiH (mutant)
    
  • 5gqb – cbChiH + chitohepatose
    
• Other chitinases
  • 1wno, 1w9p - AfChi
    
  • 2dsk - PfChi catalytic domain – Pyrococcus furiosus
    
  • 3afb - PfChi catalytic domain (mutant)
    
  • 1cns – Chi – Hordeum vulgare
    
  • 2czn, 2rts - PfChi chitin-binding domain – NMR
    
  • 2cwr - PfChi chitin-binding domain
    
  • 3ian – Chi (mutant) – Lactococcus lactis
    
  • 3fxy - hChi catalytic domain
    
  • 1lq0 - hChi residues 22-286
    
  • 1guv - hChi residues 22-387
    
  • 3fnd, 3co4 – Chi – Bacteroides thetaiotamicron
    
  • 3cql – Chi – Carica papaya
    
  • 2z37 - BjChi catalytic domain – Brassica juncea
    
  • 2z39 – BjChi catalytic domain (mutant)
    
  • 2uy2 – yChi residues 22-315 – yeast
    
  • 4hmc – MmChi 60 – Moritella marina
    
  • 4mb3 – MmChi 60 (mutant)
    
  • 3w3e – Chi – cowpea
    
  • 3w6b – RaChi catalytic domain – Ralstonia
    
  • 3w6e – RaChi catalytic domain (mutant)
    
  • 4w5z – Chi 60 catalytic domain – Vibrio marinus
    
  • 5kz6 – Chi – Bacillus anthracis
    
  • 5gzt, 5gzv, 5gzu – ChiW – Paeniacillus
    
  • 5dhd – TkChi CHBD2 domain – Thermococcus kodakarensis
    
  • 5dhe – TkChi CHBD3 domain
    
  • 5aa7 – Chi polusaccharide monooxygenase domain – Jonesia dentrificans
    
  • 4w5u – Chi 40 – Streptomyces thermoviolaceus
    
  • 4txg – Chi – Chromobacterium violaceum
    
  • 5vg0 – JdChi – Jonesia denitrificans
    
  • 5vg1 – JdChi – Neutron
    
  • 5k2l – Chi LYSM domain – Volvox carteri
    
• Other chitinases binary complex
  • 3a4w, 3a4x – PfChi catalytic domain (mutant) + NAG
    
  • 1lg1 - hChi residues 22-387 + chitobiose
    
  • 1lg2 - hChi residues 22-387 + ethylene glycol
    
  • 3fy1, 2ybt, 2ybu - hChi catalytic domain + inhibitor
    
  • 1hki, 1hkj - hChi + inhibitor
    
  • 2z38 - BjChi catalytic domain + Cl
    
  • 2uy3, 2uy4, 2uy5 - yChi residues 22-315 + inhibitor
    
  • 1w9v, 1w9u - AfChi + polypeptide
    
  • 4hmd – MmChi 60 + intermediate
    
  • 4hme – MmChi 60 + NAG
    
  • 4mb4, 4mb5 – MmChi 60 (mutant) + NAG
    
  • 3w6c – RaChi catalytic domain + disaccharide
    
  • 3w6d, 3w6f – RaChi catalytic domain (mutant) + polysaccharide
    

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Anastassis Perrakis, Marcin Jozef Suskiewicz, Michal Harel