Gelsolin

spinqualitylabelsall models Human gelsolin S4-S6 (gold) complex with actin (cyan), ATP and Ca+2 ion (green) (PDB entry 1h1v) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Gelsolin (GLS) is a protein regulator of actin assembly and disassembly. Binding of Ca+2 ion to GLS induces conformational change which enables it to bind actin. Structural highlights GLS contains 6 homologous domains S1 to S6. The human GLS domains span residues: 15-135, 136-248, 249-367, 394-513, 514-619 and 620-734. S4-S6 are shown. The binding site of Ca+2 ion includes Glu, Asp and 2 carbonyl oxygens.

3D Structures of GLS

Updated on 29-May-2018

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• GLS residues 1-782
  • 3ffn – hGLS – human
    
  • 2fgh – hoGLS+ATP – horse
    
  • 1d0n - hoGLS
    
  • 2x1o, 2x1p, 2x1q – GLS nanobody - Llama
• GLS domain S1 residues 51-178
  • 5h3m, 5h3n – hGLS – NMR
    
  • 2ff3 - hGLS +N-WASP+actin
    
  • 2ff6 - hGLS +Ciboulot domain 2+actin
    
  • [1mdu]] - hGLS +chActin – chicken
    
  • 1d4x - hGLS +CeActin+Mg-ATP – Caenorhabditis elegans
    
  • 1esv - hGLS +rActin+latrunculin – rabbit
    
  • 1eqy, 1p8z, 5ubo - hGLS +rActin
    
  • 1yvn - hGLS +yActin (mutant) – yeast
    
  • 1yag - hGLS +yActin
    
  • 1t44 - hGLS/thymosin β-4 C-terminal fusion+rActin
    
  • 1kcq, 5dd2 – hGLS +ion
    
  • 1c0f, 1mdu, 1nmd - hGLS + Actin+Ca-ATP
    
  • 1c0g, 1dej - hGLS +Actin (mutant)
    
  • 3a5l, 3a5m, 3a5n, 3a5o - hGLS (mutant)+Actin (mutant)
    
  • 3ci5, 3cip, 1nlv – DdGLS +actin - Dictyostelium discoideum
    
  • 1nm1 - DdGLS +actin+Mg-ATP
    
  • 3cjb - rGLS +rActin
    
  • 3cjc - rGLS +rActin+DNAse I
    
  • 4cbu, 4cbw, 4cbx, 5mvv - mGLS +actin+Ca+ATP
    
• GLS S2 residues 178-293
  • 5fae, 5faf, 5o2z - hGLS (mutant)
    
  • 4s10 - hGLS (mutant) + antibody
    
• GLS domains S1-S3 residues 52-426
  • 3ffk – hGLS +actin
    
  • 1rgi - hoGLS +actin
    
• GLS domains S4-S6 residues 439-782
  • 1h1v - hGLS +actin + Ca + ATP
    
  • 2fh1, 2fh2, 2fh3, 2fh4, 1p8x – hGLS + Ca
    
  • 1nph - mGLS +Ca – mouse
    

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Alexander Berchansky, Jaime Prilusky, Michal Harel