Luciferase

spinqualitylabelsall models Luciferase (PDB code 3iep) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Luciferase (Luc) or luciferin monooxygenase (Lucmo)is an oxidative enzyme used in bioluminescence. It catalyzes the oxidation of the pigment luciferin producing oxyluciferin and light. See detailed analysis in Luciola cruciata luciferase Luciferase FMN complex- Vibrio harveyi Dinoflagellate luciferase Luciferase (Hebrew). See Colored & Bioluminescent Protein. Relevance Luc is used in biological research to assess gene transfection into cells where the Luc gene is added to the transfected gene and the light emission by Luc measured for indication of the transfection success. 3D Structures of Luciferase Updated on 31-July-2018 {"openlevels":0} Luciferase 1ba3 – fLuc+bromoform - firefly 3qya – LtLuc (mutant) – Lampyris turkestanicus 4m46 – LtLuc 3fgc – VhLuc α+β chain+FMN – Vibrio harveyi 1luc, 1brl - VhLuc α+β chain 1bsl, 1xkj - VhLuc β chain Luciferin 2-monooxygenase 2psd, 2psh, 2psj, 2pse, 2psf – Luc (mutant) – Renilla reniformis 5b0u – Luc2mo (mutant) catalytic subunit – luminous shrimp Luciferin 4-monooxygenase 3iep, 1lci, 5dv9, 3ier – fLuc 5kyt, 5kyv – fLuc (mutant) 5dwv – fLuc+ substrate analog 3ies, 3rix, 4e5d – fLuc+inhibitor 4g36 – fLUc + dehydroluciferyl-sulfamoyl adenosine 4g37 – fLUc (mutant) + dehydroluciferyl-sulfamoyl adenosine 5gz2 – fLuc + thiazole derivative 5gyz – fLuc + AMP + thiazole derivative 5wys – fLuc + inhibitor 2d1q – LcLuc (mutant)+MgATP – Luciola cruciata 2d1r - LcLuc (mutant)+oxyluciferin+AMP 2d1s, 2d1t - LcLuc (mutant)+intermediate analog 2psd, 2psh, 2psj, 2pse, 2psf – Luc (mutant) – Renilla reniformis Additional information Luciferase (2d1s) Several organisms are bioluminescent, meaning that they produce light. Luciferase is one of the enzymes that catalyzes light emitting reactions in organisms. Luciola cruciata luciferase (Japanese firefly), complexed with Oxyluciferin & AMP (2d1r) or with an high-energy analogue (2d1s) 3ies,3iep and 3ier Firefly luciferase (FLuc) bound to its natural substrate ATP and the inhibitor PTC124 1ba3 firefly luciferase enzyme from Photinus pyralis 2psd, 2pse, 2psf, 2psh, 2psj, and 2rh7 the luciferase from Renilla reniformis (RLuc) 1bsl 1.95Å heterodimer of bacterial luciferase from Vibrio harveyi 1brl 2.4Å heterodimer of bacterial luciferase from Vibrio harveyi 1xkj homodimer of bacterial luciferase from Vibrio harveyi 2d1q, 2d1r and 2d1s thermostable Japanese Firefly (Luciola cruciata) Luciferase complexed with High-energy intermediate analog 2d1t thermostable Japanese Firefly Luciferase red-color emission S286N mutant 1lci firefly luciferase enzyme from Photinus pyralis Dinoflagellate luciferase 1luc The 1.5Å resolution crystal structure of bacterial luciferase from Vibrio harveyi 3fgc Bacterial luciferase from Vibrio harveyi 1vpr luciferase of Lingulodinium polyedrum, a marine bioluminescent dinoflagellate Green Fluorescent Protein For additional information, see: Colored & Bioluminescent Proteins

External Resources

• Yahoo news coverage of luciferase studies funded research for military applications
• Luciferase at Wikipedia
• Luciferase: June 2006 Molecule of the Month as part of the series of tutorials that are at the RCSB Protein Data Bank and written by David S. Goodsell

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Wayne Decatur, Alexander Berchansky, David Canner, Loïc Gazquez, Charlene Planchenault, Michal Harel