6d24 | pdb_00006d24

Trypanosoma cruzi Glucose-6-P Dehydrogenase in complex with G6P

spinqualitylabelsall models 6d24, resolution 3.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6d24 is a 4 chain structure with sequence from Trycr. This structure supersedes the now removed PDB entry 4em5. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BG6, CL, GOL, SO4 NonStd Res: CSO Gene: G6PDH1 (TRYCR) Activity: Glucose-6-phosphate dehydrogenase, with EC number 1.1.1.49 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed An N-terminally truncated version of the enzyme glucose-6-phosphate dehydrogenase from Trypanosoma cruzi lacking the first 37 residues was crystallized both in its apo form and in a binary complex with glucose 6-phosphate. The crystals both belonged to space group P2(1) and diffracted to 2.85 and 3.35 A resolution, respectively. Self-rotation function maps were consistent with point group 222. The structure was solved by molecular replacement, confirming a tetrameric quaternary structure. Expression, crystallization and preliminary X-ray crystallographic analysis of glucose-6-phosphate dehydrogenase from the human pathogen Trypanosoma cruzi in complex with substrate.,Ortiz C, Larrieux N, Medeiros A, Botti H, Comini M, Buschiazzo A Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1457-61., Epub 2011 Oct 27. PMID:22102256 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Glucose 6-phosphate dehydrogenase

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