Spectrin

spinqualitylabelsall models Human spectrinα (grey) and β1 chain (green) 3lbx Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Spectrin forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. Disease Mutations in SPT α are found in patients with hereditary elliptocytosis. SPT β deficiency is found in hereditary spherocytosis.

3D Structures of Spectrin

Updated on 20-September-2018

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• Spectrin α1
  • 3lbx – hSPTA1+hSPTB1 – human
    
  • 3i9q, 2rot, 2oaw, 2nuz, 1u06 - cSPTA1 SH3 domain – chicken
    
  • 2jm8, 2jm9, 2cdt, 2f2v, 2f2w, 2f2x - cSPTA1 SH3 domain (mutant)
    
  • 2jma, 2jmc - cSPTA1 SH3 domain (mutant)+P41 peptide
    
  • 2rmo, 1neg, 1m8m - cSPTA1 SH3 domain – NMR
• Spectrin α2
  • 3f31 – hSPTA2 tetramerization domain
    
  • 5fw9, 5fwb, 5fwc, 5ihi, 5ihk, 5ihn – hSPTA2 SH3 domain (mutant)
    
  • 1qkw – cSPTA2 SH3 domain (mutant)
    
  • 2fot - SPTA2+calmodulin – bovine
    
  • 3fb2 – hSPTA2 repeats 15-16
    
  • 3thk - SPTA2 SH3 domain + polypeptide - rat
• Spectrin α
  • 2kr3, 4f17, 4f16 - cSPTA SH3 domain
    
  • 1e6g, 1e6h, 1hd3, 1qkx, 1pwt, 1bk2, 1shg, 1h8k, 3ngp, 3m0p, 3m0q, 3m0r, 3m0s, 3m0t, 3m0u - cSPTA SH3 domain (mutant)
    
  • 1uue, 1e7o, 1g2b, 1aey, 1tuc, 1tud - cSPTA SH3 domain (mutant) – NMR
    
  • 2lj3 - cSPTA SH3 domain – NMR
    
  • 1u4q – cSPTA repeats 15-17
    
  • 1u5p - cSPTA repeats 15-16
    
  • 1cun - cSPTA repeats 16-17
    
  • 1aj3 - cSPTA repeat 16 - NMR
    
  • 1owa - hSPTA tetramerization domain – NMR
    
  • 5j4o - hSPTA repeats 16-17
    
• Spectrin β1
  • 3bkt, 3kbu - hSPTB1+ankyrin
    
  • 3f57, 3edu - hSPTB1 ankyrin binding domain
    
  • 1s35 – hSPTB1 repeats 8-9
• Spectrin β2
  • 3edv – hSPTB2 repeats 14-16
• Spectrin β3
  • 1wyq – hSPTB3 CH domain – NMR
    
  • 1wjm – hSPTB3 – NMR
    
  • 6anu - hSPTB3 ankyrin binding domain + actin - Cryo EM
    
• Spectrin β
  • 1bkr, 1aa2 – hSPTB CH domain
    
  • 1mph – SPTB Pleckstrin Homology domain – NMR
    
  • 1dro - mSPTB PH domain – NMR – mouse
    
  • 1btn – mSPTB+inositol phosphate
    
  • 2spc – SPT fragment - Drosophila melanogaster
• Spectrin R16
  • 5m6s – SPT - Escherichia coli
    

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel