|
Function
Gephyrin (Gep) is responsible for Mo cofactor biosynthesis and for postsynaptic clustering of glycine receptors and type A GABA receptors in the vertebrate CNS. Gep self-assembles to form scaffolds in the synapse[1].
Relevance
Abnormal accumulation of Gep are highly correlated with the neuropathologic diagnosos of Alzheimer Disease[2].
Structural highlights
- ↑ Tyagarajan SK, Fritschy JM. Gephyrin: a master regulator of neuronal function? Nat Rev Neurosci. 2014 Mar;15(3):141-56. doi: 10.1038/nrn3670. PMID:24552784 doi:https://dx.doi.org/10.1038/nrn3670
- ↑ Hales CM, Rees H, Seyfried NT, Dammer EB, Duong DM, Gearing M, Montine TJ, Troncoso JC, Thambisetty M, Levey AI, Lah JJ, Wingo TS. Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes. J Neuropathol Exp Neurol. 2013 Nov;72(11):1009-15. doi:, 10.1097/01.jnen.0000435847.59828.db. PMID:24128675 doi:https://dx.doi.org/10.1097/01.jnen.0000435847.59828.db
|
3D structures of gephyrin
Updated on 29-October-2018
2fu3, 5erq, 4pd0 - rGeph E domain 318-736 - rat
2fts, 4pd1, 1t3e, 4u91 - rGeph E domain + glycine receptor peptide
4tk1, 4tk2, 4tk3, 4tk4, 4u90 - rGeph E domain + GABA receptor peptide
5ers - rGeph E domain + AMP
5ert, 5err - rGeph E domain + ADP
5eru - rGeph E domain + ADP + Mo + MoO4
5erv - rGeph E domain + ADP + W + WO4
1thc - rGeph N terminal
References
