Gephyrin

spinqualitylabelsall models Rat gephyrin E domain (cyan) complex with glycine receptor peptides (magenta and violet), acetate and Ca+2 ion (green) (PDB code 4u91) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Gephyrin (Gep) is responsible for Mo cofactor biosynthesis and for postsynaptic clustering of glycine receptors and type A GABA receptors in the vertebrate CNS. Gep self-assembles to form scaffolds in the synapse. Relevance Abnormal accumulation of Gep are highly correlated with the neuropathologic diagnosis of Alzheimer Disease. Structural highlights Para-Phenyl crosslinked Glycine receptor beta subunit derived dimeric peptide interacts with several side chains of Gep. 1,1'-benzene-1,4-diylbis(1H-pyrrole-2,5-dione) crosslinking with peptides

3D structures of gephyrin

Updated on 30-October-2018

2fu3, 5erq, 4pd0 - rGeph E domain 318-736 - rat
2fts, 4pd1, 1t3e, 4u91 - rGeph E domain + glycine receptor peptide
4tk1, 4tk2, 4tk3, 4tk4, 4u90 - rGeph E domain + GABA receptor peptide
5ers - rGeph E domain + AMP
5ert, 5err - rGeph E domain + ADP
5eru - rGeph E domain + ADP + Mo + MoO4
5erv - rGeph E domain + ADP + W + WO4
1thc - rGeph N terminal

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