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Function
Negative elongation factor (NELF) induces RNA polymerase II promoter proximal pausing and limits provirus expression in HIV-infected T cells[1].
Disease
NELF has been implicated in various diseases ranging from neurological disorders to cancer[2].
Structural highlights
- ↑ Natarajan M, Schiralli Lester GM, Lee C, Missra A, Wasserman GA, Steffen M, Gilmour DS, Henderson AJ. Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription. J Biol Chem. 2013 Sep 6;288(36):25995-6003. doi: 10.1074/jbc.M113.496489. Epub, 2013 Jul 24. PMID:23884411 doi:https://dx.doi.org/10.1074/jbc.M113.496489
- ↑ Yung TM, Narita T, Komori T, Yamaguchi Y, Handa H. Cellular dynamics of the negative transcription elongation factor NELF. Exp Cell Res. 2009 Jun 10;315(10):1693-705. doi: 10.1016/j.yexcr.2009.02.013., Epub 2009 Feb 23. PMID:19245807 doi:https://dx.doi.org/10.1016/j.yexcr.2009.02.013
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3D structures of negative elongation factor
Updated on 31-October-2018
5l3x - hNELF A + NELF C/D - human
2bz2, 1x5p, 2jx2 - hNELF E RNA recognition motif - NMR
6gml - NELF A + NELF B + NELF C + NELF D + NELF E + RNA polymerase II + transcription elongation factors SPT4-SPT5 + DNA + RNA + - pig - Cryo EM
References
