This is a default text for your page Colony-stimulating factor. Click above on edit this page to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function
Colony-stimulating factors (CSF) are growth regulatory factors which influence functional activity, survival, proliferation and differentiation of myeloid mature and haemopoietic cells. Three distinct CSFs were characterized[3].
- Granulocyte colony-stimulating factor (G-CSF) act on proliferation, functional stimulation and differentiation of progenitors of neutrophils.
- Granulocyte-macrophage colony-stimulating factor (GM-CSF) act on proliferation, functional stimulation and differentiation of progenitors of neutrophils, monocytes and granulocytes.
- Macrophage colony-stimulating factor (M-CSF) act on proliferation, functional stimulation and differentiation of progenitors of monocytes and macrophages.
Disease
Relevance
Depletin o CSFs have therapeutic benefit in many inflammatory and autoimmune conditions[4].
Structural highlights
This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:https://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Nemunaitis J. A comparative review of colony-stimulating factors. Drugs. 1997 Nov;54(5):709-29. doi: 10.2165/00003495-199754050-00004. PMID:9360058 doi:https://dx.doi.org/10.2165/00003495-199754050-00004
- ↑ Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008 Jul;8(7):533-44. doi: 10.1038/nri2356. PMID:18551128 doi:https://dx.doi.org/10.1038/nri2356
