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Function
Colony-stimulating factor receptor (CSFR) are binding the Colony-stimulating factors and thus mediating the lineage-specific growth of cells of the mononuclear phagocytes series as bone marrow-derived precursors of monocytes and macrophages[1]. The granulocyte colony stimulating factor receptor (G-CSFR) participates in the development, survival and activation of neutrophilic granulocytes and in the development of other myeloid lineages.
Disease
Mutations in G-CSFR were found in patients with severe congenital neutropenia[2].
Relevance
Structural highlights
- ↑ Sherr CJ, Roussel MF, Rettenmier CW. Colony-stimulating factor-1 receptor (c-fms). J Cell Biochem. 1988 Nov;38(3):179-87. doi: 10.1002/jcb.240380305. PMID:2852667 doi:https://dx.doi.org/10.1002/jcb.240380305
- ↑ Dong F, Dale DC, Bonilla MA, Freedman M, Fasth A, Neijens HJ, Palmblad J, Briars GL, Carlsson G, Veerman AJ, Welte K, Lowenberg B, Touw IP. Mutations in the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia. Leukemia. 1997 Jan;11(1):120-5. PMID:9001427
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3D structures of colony-stimulating factor receptor
Updated on 15-November-2018
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- Macrophage colony stimulating factor 1 receptor or C-FMS; Domains: kinase 543-918; 2nd Igg-like 129-229; D1-D3 20-299; ectodomain 2-512
- M-CSFR complex
- 2i0v, 2i0y, 2i1m, 3lco - hM-CSFR kinase domain + inhibitor
- 3dpk, 3bea, 4hw7, 4r7h, 3krj, 3krl, 3lcd - hM-CSFR kinase domain (mutant) + inhibitor
- 1flt, 1qty – hM-CSFR 2nd Igg-like domain + VEGF
- 4wrm, 4wrl - hM-CSFR + M-CSF
- 3ejj – mM-CSFR D1-D3 + M-CSF
- 4exp – mM-CSFR D1-D3 + mInterleukin 34
- 4dkd – hM-CSFR D1-D3 + hInterleukin 34
- 4r7i – hM-CSFR kinase domain (mutant) + cancer drug
- 4liq – hM-CSFR ectodomain + antibody
- Granulocyte-macrophage colony stimulating factor receptor
- 4rs1 - hGM-CSFR subunit a (mutant) + GM-CSF
- 4nkq - hGM-CSF CSFR subunit a (mutant) + GMCSF + cytokine receptor
- Granulocyte colony stimulating factor receptor or colony stimulating factor 3 receptor
- 1gcf, 1cto - mG-CSFR C-terminal (mutant) - NMR
- 2d9q - hG-CSFR Ig-CRH domain (mutant) + hG-CSF
- 1pgr, 1cd9 - mG-CSFR CRH domain + hG-CSF
References
