Syntaxin

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Syntaxin (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles. Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs. Relevance The blockade of Stx-1 inhibits glioblastoma tumor growth and may represent a novel therapeutic tool against this fatal tumor.

3D structures of syntaxin

Updated on 25-November-2018

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• Syntaxin 1
  • 2xhe – Stx1 + Unc18 – Monosiga brevicollis
    
• Syntaxin 1A
  • 1ez3 – rStx1a N-terminal – rat
    
  • 1br0 – rStx1a N-terminal (mutant) – NMR
    
  • 1hvv – rStx1a SNARE motif
    
  • 2m8r – rStx1a SNARE motif - NMR
    
  • 1jth – rStx1a SNARE motif + SNAP25
    
  • 1urq – rStx1a SNARE motif + SNAP25 + tomosyn
    
  • 1n7s, 3h7d, 1sfc, 3ipd, 3rk2, 3rl0 – rStx1a SNARE motif + SNAP25 + VAMP2
    
  • 3rk3 – rStx1a SNARE motif + SNAP25 + complexin-1 + VAMP2
    
  • 5ccg, 5cch, 5cci, 5kj7, 5kj8 – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2
    
  • 2n1t – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 - NMR
    
  • 3c98, 4jeh, 4jeu – rStx1a + Unc18
    
• Syntaxin 6
  • 1lvf – rStx6 N-terminal
    
  • 4j2c – hStx6 + vacuolar protein sorting-associated protein peptide – human
    
• Syntaxin 7
  • 1gl2 – mStx7 core fragment + VAMP8 + rStx8 core fragment + VTI1-RP2 - mouse
    
• Syntaxin 10
  • 4dnd – hStx10
    
• Syntaxin 12
  • 2dnx – hStx12 N-terminal - NMR
    
• Syntaxin 13
  • 2nps – rStx13 SNARE motif + VAMP2 + hStx6 SNARE motif + VTI1-RP2
    
• Syntaxin 17
  • 4wy4 – rStx17 SNARE motif + SNAP25 + VAMP2
    
• s-syntaxin
  • 1s94 – LpStx Habc domain – Loligo pealei
    
  • 1l4a – LpStx1a SNARE motif + SNAP25 + synaptobrevin + synaphin A
    
• Syntaxin VAM3
  • 1hs7 – Stx N-terminal – yeast - NMR
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky