Cadherin

spinqualitylabelsall models Mouse cadherin-11 EC1 dimer (PDB code 2a4c) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons), P-CDH (placental), K-CDH (kidney). The CDH superfamily contains: *Protocadhedrins (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains. They are found mainly in the brain at cell-cell contacts. Desmogleins (Des-CDH) are CDH found in desmosomes. Structural highlights The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed strand swap. The strand swapping is enhanced by 2 Trp residues docking into the hydrophobic pocket of the neighboring CDH molecule.

3D Structures of Cadherin

Updated on 08-January-2019

{"openlevels":0}

• CDH5
  • 2koh – mCDH5+PAR3-PDZ3 - mouse
    
• CDH6
  • 3lnd – mCDH6 EC12 (mutant)
    
• CDH8
  • 1zxk – mCDH8 EC1
    
  • 2a62 - mCDH8 EC1-EC3
    
• CDH11
  • 2a4c, 2a4e – mCDH11 EC1
    
• CDH20
  • 1zvn – cCDH20 EC1 – chicken
    
• CDH23
  • 3mvs, 2whv – mCDH23 N-terminal
    
  • 2kbr – hCDH23 peptide+harmonin – NMR - human
    
  • 2kbs - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR
    
  • 2wbx – mCDH23 EC1
    
  • 2wcp - mCDH23 EC2
    
  • 2wd0 - mCDH23 EC1-EC2 (mutant)
    
  • 5tfm - mCDH23 EC6-EC8
    
  • 5tfl - mCDH23 EC7-EC8
    
  • 5tfk - mCDH23 EC19-EC21
    
  • 5i8d, 5ulu, 5un2 - mCDH23 EC19-EC21 (mutant)
    
  • 5uz8 - mCDH23 EC22-EC24
    
  • 4apx, 4aq8, 4axw, 4xxw - mCDH23 EC1-EC2 + Prot-CDH15
    
  • 4aqa, 4aqe - mCDH23 EC1-EC2 (mutant) + Prot-CDH15
• C-CDH “classical”
  • 1l3w – XlC-CDH ectodomain - Xenopus laevis
    
  • 1q5b, 1q5c, 1q55, 1q5a – C-CDH model into desmosome – electron tomography
    
• E-CDH epithelial or CDH1
  • 1q1p, 1ff5, 1edh, 3lne, 3lnf, 3lng, 3lnh, 3lni, 2qvf – mE-CDH EC1-EC2
    
  • 3q2v – mE-CDH ectodomain
    
  • 4zt1, 2o72 – hE-CDH EC1-EC2
    
  • 4zte – hE-CDH EC1-EC2 + inhibitor
    
  • 1edh - mE-CDH EC1-EC2+Ca
    
  • 3q2l, 3q2n, 3qrb - mE-CDH EC1-EC2 (mutant)
    
  • 1suh – mE-CDH N-terminal - NMR
    
  • 1i7x, 1i7w – mE-CDH cytoplasmic domain +catenin
    
  • 4qd2 – mE-CDH + botulinum neurotoxin
    
  • 3ifq – hE-CDH EC1-EC3
    
  • 3ff7, 3ff8 - hE-CDH EC1-EC3+NK cell receptor
    
  • 2omt, 2omu, 2omx, 2omz, 2omv, 2omw, 2omy – hE-CDH EC1+internalin (mutant)
    
  • 1o6s – E-CDH N-terminal+internalin – Listeria monocytogenes
    
  • 4qd2 – mE-CDH + botulinum neurotoxin
    
• K-CDH kidney or CDH6
  • 5veb – hK-CDH EC5 + antibody
    
• T-CDH membrane bound
  • 3k5r – mT-CDH EC1-EC2
    
  • 3k5s - cT-CDH EC1-EC2
    
  • 3k6d - XlT-CDH EC1
    
  • 3k6f - mT-CDH EC1
    
  • 3k6i - cT-CDH EC1
    
  • 2v37 – hT-CDH N-terminal - NMR
    
• N-CDH neuronal
  • 1nch, 1nci – mN-CDH
    
  • 1ncg – mN-CDH (mutant)
    
  • 2qvi, 4nuq – mN-CDH EC1-EC2
    
  • 4num, 4nup – mN-CDH EC1-EC2 (mutant)
    
  • 1ncj – mN-CDH two domains
    
  • 3q2w – mN-CDH ectodomain
    
  • 1op4 - mN-CDH prodomain - NMR
    
  • 3ubf – DmN-CDH ectodomain – Drosophila melanogaster
    
  • 3ubh - DmN-CDH EC1-EC4
    
  • 3ubg - DmN-CDH EC1-EC3
• P-CDH placental or CDH3
  • 4nqq – mP-CDH EC1-EC2
    
  • 4oy9, 4zml, 4zmn, 4zmq, 4zmt, 4zmw, 4zmz – hP-CDH EC1-EC2
    
  • 4zmo, 4zmp, 4zmv, 4zmx, 4zmy – hP-CDH EC1-EC2 (mutant)
    
  • 5jyl, 5jym – hP-CDH EC1-EC2 + SCFV TSP7
    
• VE-CDH vascular epithelial
  • 3ppe – cVE-CDH EC1+EC2
    
• Protocadherin
  • 2yst – hProt-CDH7 EC3 – NMR
    
  • 2ee0 - hProt-CDH9 Ca domain – NMR
    
  • 1wyj - mProt-CDH β 14 - NMR
    
  • 1wuz - mProt-CDH4 EC1 – NMR
    
  • 5cyx - mProt-CDH2 EC1+EC2+EC3
    
• Desmoglein
  • 2yqg – hDes-CDH2 EC1
    
  • 5erd – hDes-CDH2 ectodomain
    
  • 5eqx – hDes-CDH3 ectodomain
    
• Desmocollin
  • 5iry – hDesmc1 ectodomain
    
  • 5erp, 5j5j – hDesmc2 ectodomain
    

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel