CREB-binding protein

spinqualitylabelsall models Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions 3p1c Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function CREB-binding protein (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. Disease Mutations in CBP cause Rubinstein-Taybi syndrome. Structural highlights CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73. Acetyllysine binding site with chain A. Water molecules are shown as red spheres. Acetyllysine binding site with chain B (3p1c).

3D Structures of CREB-binding protein

Updated on 18-February-2019

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• CBP
  • 3p1c – mCBP GACKIX domain (mutant) - mouse
    
  • 1f81 – mCBP TAZ2 domain - NMR
    
  • 1u2n – mCBP TAZ1 domain - NMR
    
  • 1jjs – mCBP IBiD domain - NMR
    
  • 1liq – mCBP CH1 domain - NMR
    
  • 1tot – mCBP ZZ domain – NMR
    
  • 2kkj – mCBP nuclear coactivator binding domain - NMR
    
  • 1wo3, 1wo4, 1wo5, 1wo6, 1wo7 – hCBP zinc finger domain (mutant) – human - NMR
    
  • 2d82 – hCBP bromodomain - NMR
    
  • 3dwy, 4ouf, 4whu – hCBP bromodomain
    
  • 3p1c, 3p1d, 3p1e, 3p1f, 3svh, 4a9k, 4tqn, 4ts8, 4yk0, 5cgp, 5dbm, 5eic, 5eng, 5ep7, 5h85, 5i83, 5i86, 5i89, 5i8b, 5i8g, 5j0d, 5ktu, 5ktw, 5ktx, 5tb6 – hCBP bromodomain + inhibitor
    
  • 2l84, 2l85 – hCBP bromodomain + inhibitor - NMR
    
• CBP complex with protein
  • 1kbh – hCBP + nuclear receptor coactivator - NMR
    
  • 1zoq – hCBP + interferon regulatory factor 3
    
  • 2c52 – mCBP residues 2059-2117 + nuclear receptor coactivator - NMR
    
  • 1r8u – mCBP TAZ1 domain + P300-interacting transactivator - NMR
    
  • 1l8c – mCBP TAZ1 domain + hypoxia-inducible factor 1α - NMR
    
  • 2lww - mCBP TAZ1 domain + nuclear transcription factor RELA – NMR
    
  • 2ka6 – mCBP TAZ2 domain + STAT1-TAD - NMR
    
  • 2ka4 – mCBP TAZ2 domain + STAT2-TAD - NMR
    
  • 2n1a – hCBP + small ubiquitin-related modifier - NMR
    
  • 5jem – hCBP residues 2065-2111 + interferon-3
    
  • 1kdx – mCBP KIX domain + CREB kinase inducible domain - NMR
    
  • 2kje – hCBP TAZ2 domain + adenoviral E1A peptide - NMR
    
  • 1jsp – hCBP bromodomain + p53 peptide - NMR
    
  • 2l14 – mCBP nuclear coactivator binding domain + p53 peptide - NMR
    
  • 1sb0 – mCBP KIX domain + protein c-Myb – NMR
    
  • 2agh – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR
    
  • 2lqh, 2lqi – mCBP KIX domain + forkhead box O3 – NMR
    
  • 2kwf – hCBP KIX domain + transcription factor 4 – NMR
    
  • 2lxs, 2lxt – hCBP KIX domain + histone methyltransferase MLL peptide – NMR
    
  • 2rny – hCBP bromodomain + histone H3 peptide - NMR
    
  • 4n3w, 4n4f - hCBP bromodomain + histone H4 peptide
    
  • 4nr4, 4nr5, 4nr6, 4nr7, 4nyv, 4nyw, 4nyx- hCBP bromodomain + ligand
    

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Michal Harel, Alexander Berchansky