Factor VIII

spinqualitylabelsall models Glycosylated human Factor VIII. Residues 19-760 (cyan), 1582-2351 (magenta) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code 2r7e) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Factor VIII (FVIII) is a blood clotting factor. FVIII is a cofactor for factor IXa . See also Factor VIII (Hebrew). First Ca coordination site. Second Ca coordination site. First Cu coordination site. Second Cu coordination site (PDB code 2r7e). Disease Defects in the protein result in hemophilia A. Relevance Factor VIII is given to hemophiliacs in order to restore homestasis.

3D Structures of Factor VIII

Updated on 17-March-2019

factor IXa, Factor VIII (Hebrew), 2r7e, 4bdv – hFVIII – human
3hnb, 3hny, 3hob – hFVIII light chain C2 domain
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
4xzu - hFVIII light chain C2 domain + monoclonal Fab
4pt6 - hFVIII discoidin domain
4ki5 - mFVIII light chain C2 domain + monoclonal Fab – mouse
3j2s - hFVIII light chain
5k8d - hFVIII heavy chain + light chain residus 104-329
4mo3 - FVIII light chain C2 domain – pig

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Alexander Berchansky, Michal Harel