Response regulator

spinqualitylabelsall models Se-Met DNA-binding response regulator D complex with thiocyanate, 1kgs Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Response regulators (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal which is the signal receiving domain and C terminal which is the DNA-binding domain (DBD). RR CheY is a chemotaxis response regulator in bacteria see Chemotaxis protein.. RR Spo0 is the sporulation response regulator. RR PleD is required in loss of motility. For details see PleD activation, PleD allosteric product inhibition, PleD catalysis and Response regulator PLED in complex with C-di-GMP RR PhoP is important for survival under conditions of macrophage-induced stress. For details see PhoP Regulatory Domain and PhoP-PhoQ Photosynthetic apparatus RR in Rhodobacter sphaeroides is involved in the transduction of signals which monitor oxygen levels. . For details see PrrA in Rhodobacter sphaeroides RR WspR couples the chemosensory Wsp pathway to the overproduction of acetylated cellulase . For details see WspR. Redox RR is DNA-sequence specific. It controls transcription as a result of its phosphorylation by a redox sensor. For iron response regulator Irr see Irr.

3D Structures of response regulator

Updated on 15-August-2019

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• Nitrate/nitrite response regulator
  • Chemotaxis protein, PleD activation – EcNarL – Escherichia coli
    
  • PleD allosteric product inhibition, PleD catalysis, Response regulator PLED in complex with C-di-GMP – EcNarL DNA-binding domain + DNA
• Sporulation response regulator
  • PhoP Regulatory Domain, PhoP-PhoQ, PrrA in Rhodobacter sphaeroides, WspR – BsSpo0F (mutant) – Bacillus subtilis
    
  • Irr - BsSpo0F
    
  • 3q15 - BsSpo0F + RR aspartate phosphatase
    
  • 1ixm - BsSpo0B
    
  • 1fc3 – GsSpo0A trans-activation domain – Geobacillus stearothermophilus
    
  • 1dz3, 1qmp - GsSpo0A reciever domain
• DNA-binding response regulator
  • 1kgs, 5u8k – TmDrrD – Thermotoga maritima
    
  • 3nnn – TmDrrD receiver domain + BeF3
    
  • 1p2f – TmDrrB
    
  • 3nns - TmDrrB receiver domain + BeF3
    
  • 1nxo, 1nxp, 1nxs, 1nxt, 1nxv, 1nxw, 1nxx – SpMicArec receiver domain – Streptococcus pneumonia
    
  • 2gwr - MtMtrA – Mycobacterium tuberculosis
    
  • 2hwv – EfVicR C terminal – Enterococcus faecalis
    
  • 5hev – EfVraR
    
  • 2qsj – LuxR – Silicibbacter pomeroyi
    
  • 3cnb, 3eqz – MerR receiver domain – Colwellia psychrerythraea
    
  • 2rnj – SaVraR DBD – Staphylococcus aureus – NMR
    
  • 2zxj - SaWalR DBD
    
  • 4qwq - SaSaeR DNA-binding domain
    
  • 4ixa – SaeR DNA-binding domain – Staphylococcus epidermidis
    
  • 4gvp – SaVraR
    
  • 4if4 – SaVraR + Mg + BeF3
    
  • 3q9s – DrRR receiver domain – Deinococcus radiodurans
    
  • 3q9v - DrRR C terminal
    
  • 3rjp - RR DBD – Streptococcus pyogenes
    
  • 2a9r – SpRR N terminal + phosphate + Mg
• Cyanobacterial phytochrome response regulator
  • 1i3c – SyRcp1 – Synechocystis
    
  • 1jlk – SyRcp1 + Mn
    
  • 1k66 – ToRcpB – Tolypothrix
    
  • 1k68 – ToRcpB
• Phosphatase synthesis response regulator
  • 1mvo – BsPhoP receiver domain
    
  • 2jb9, 2jba – EcPhoB (mutant)
    
  • 2pmu – MtPhoP DBD
• Polar differentiation response regulator
  • 1m5t, 1m5u – CvDivK – Caulobacter vibrioides
    
  • 1mav, 1mb0, 1mb3 – CvDivK + cation
• Photosynthetic apparatus response regulator
  • 1umq – PrrA DBD – Rhodobacter sphaeroides – NMR
    
  • 1ys6 – MtPrrA
    
  • 1ys7 – MtPrrA + Mg
• Redox response regulator
  • 1xhe – EcArcA receiver domain
    
  • 1xhf – EcArcA receiver domain + BeF3
    
  • 4ynr - MtDevs GAF domain + CO
    
  • 4yof - MtDevs GAF domain + NO
    
  • 2y79 – MtDevs GAF domain (mutant)
    
  • 3zxo - MtDevs ATP-binding domain (mutant)
    
  • 5vfa – SpRR (mutant)
    
• Social motility response regulator
  • 2gkg, 2i6f – MxFrzS receiver domain – Myxococcus xanthus
    
  • 2nt3, 2nt4 - MxFrzS receiver domain (mutant)
• Stalked-cell differentiation response regulator
  • 2v0n – CvPleD + GMP + GTP
    
  • 2wb4, 1w25 - CvPleD + GMP
• Hypoxia response regulator
  • 3c3w, 1zlj – MtDosR
    
  • 3c57 – MtDosR C terminal
    
  • 1zlk – MtDosR C terminal + DNA
    
  • 3zxo – MtDost ATP-binding domain
    
• Transcriptional response regulator
  • 2zwm – BsYycF receiver domain
    
  • 5iuj, 5iuk, 5iul, 5iun - BsDesR + DesK
    
  • 3ulq – BsComA DBD + RR aspartate phosphatase
    
  • 2pkx – EcPhoP regulatory domain
    
  • 5ed4 - MtPhoP + DNA
    
  • 3nhz – MtMtra N terminal
    
  • 5fmn - SyInrS
    
  • 5lwk - LpMaeR + BeF3 - Lactobacillus paracasei
    
  • 5lwl - LpMaeR (mutant)
    
  • 4g9y - ScPcaV - Streptomyces coelicolor
    
  • 4fht - ScPcaV + hydroxybenzoic acid
    
  • 4u88 - SaSaeR DBD
    
  • 4ixa - SaeR DBD - Staphylococcus epidermidis
    
  • 4so5 - BasR + DNA - Klebsiella pneumoniae
    
• Stress response regulator
  • 3n0r – CVPhyR
    
  • 5i4c - EcRcsB receiver domain
    
  • 3cra, 3crc - EcMazG
    
  • 2v42, 2v43 - EcRseB
    
• Chemotaxis response regulator see Chemotaxis protein
• Two-component response regulator
  • 2lpm – SmRR
    
  • 2m98 – RR – Sinorhizobium meliloti
    
  • 4q7e – RR receiver domain – Leptospira biflexa
    
  • 2qr3 – RR N terminal – Bacteroides fragilis
    
  • 2qzj – RR – Clostridium difficile
    
  • 3cz5 – RR – Aurantimonas
    
  • 2qvg - RR - Legionella pneumophila
    
  • 3ilh - RR - Cytophaga hutchinsonii
    
  • 5brj - RR - Agrobacterium tumefaciens
    
  • 5uic - QseB - Francisella tularensis
    
  • 3lsg - RR C-terminal - Fusobacterium nucleatum
    
  • 3p01 - RR - Nostoc
    
  • 6br7 – RR receiver domain – Acinetobacter
    
  • 5u8m – SpRR
    
  • 5t3y – RR - Burkholderia multivorans
    
  • 4yn8 – RR – Corynebacterium diphtheriae
    
• Fixj RR
  • 5xso, 5xt2 – RR – Bradyrhizobium japonicum
    
• response regulator receiver domain protein
  • 4wsz – EfRR
    
  • 3c3m – RR – Methanoculleus marisnigri
    
  • 3heb - RR – Rhodospirillum rubrum
    
  • 3lte – RR – Bermanella marisrubri
    
  • 3jte, 3lua – RR – Clostridium thermocellum
    
  • 4wt0 – EfRR DNA-binding domain (mutant)
    
  • 4wu4, 4wuh, 4wul – EfRR DNA-binding domain + DNA
    
  • 4xlt – RR – Dyadobacter fermentans
    
• Unspecified response regulator
  • 1yio, 1zn2 – StyR – Pseudomonas fluorescens
    
  • 3a0u, 3a10 – TmTrrA + Mg + BeF3
    
  • 2qvg – RR – Legionella pneumophila
    
  • 3gl9, 2qxy, 4ja2 - TmRR
    
  • 4hye – SpRR
    
  • 2zay – RR – Desulfuromonas acetoxidans
    
  • 2rdm – RR (mutant) – Sinorhizobium medicae
    
  • 3hdv – RR – Pseudomonas putida
    
  • 3i5a – PsWspR – Pseudomonas syringae
    
  • 3ilh – RR – Cytophaga hutchinsonii
    
  • 3i5b – PaWspR GGDEF domain
    
  • 3i5c – PaWspR GGDEF domain/GCN4 leucine zipper
    
  • 3ljx – McMmoQ – Methylococcus capsulatus
    
  • 3p3q – McMmoQ (mutant)
    
  • 3lsg – RR C terminal – Fusobacterium nucleatum
    
  • 3nhm – MxRR
    
  • 3m6m – XcRpfC REC domain + enoyl-CoA hydratase – Xanthomonas campestris
    
  • 3qyy – XcRR GGDEF domain + GMP
    
  • 3p01 – RR residues 134-315 – Nostoc
    
  • 3rqi – RR + phosphate + Ca + citrate – Burkholderia pseudomallei
    
  • 5tqj, 5te9 – RR - Burkholderia phymatum
    
  • 5e3j – RR Rsta – Acinetobacter baumannii
    
  • 4qpj – RR Ctra + phosphotransferase – Brucella abortus
    
  • 3kto – RR - Pseudoalteromonas atlantica
    
  • 3t0y – CvRR anti-anti-σ domain + anti-σ factor NEPR
    
  • 2oqr – MtRR Regx3
    
  • 3sy8 – PaRR Rocr
    
  • 4ml3, 4mld – SpRR Rec domain (mutant)
    
  • 4cbv – SpRR (mutant)
    
  • 2a9o, 2a9p, 6ebb – SpRR + Mn + BeF3
    
  • 4zms ,4zmr - SpRR + Mg + BeF3
    
  • 2pln – HP1043 – Helicobacter pylori
    
  • 3kht – RR – Hahella chejuensis
• Response regulator complex with histidine kinase
  • 3dge, 3dgf – TmRR + sensor protein
    
  • 3a0r – TmTrrA (mutant) + sensor protein
    
  • 4jas, 4jav – TmRR (mutant) + histidine kinase
    
  • 5uht – TmRR + sensor histidine kinase
    

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky