6ash | pdb_00006ash

Crystal structure of human Cathepsin K with a non-active site inhibitor at 1.42 Angstrom resolution

spinqualitylabelsall models 6ash, resolution 1.42Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6ash is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 1XF Gene: CTSK, CTSO, CTSO2 (HUMAN) Activity: Cathepsin K, with EC number 3.4.22.38 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Function [CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. See Also Cathepsin 3D structures

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