Insulin 3D Structures

(Updated on 29-August-2019)

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• Insulin
  • 3i3z, 3i40, 3e7y, 3e7z, 2qiu, 2c8q, 2c8r, 1q4v, 1os3, 1os4, 1mso, 1guj, 1g7a, 1g7b, 1xda, 1trz, 3zqr, 3zs2, 3zu1, 2lgb, 3v19, 3v1g, 4ajx, 4ajz, 4ak0, 4akj, 4eww, 4ewx, 4ewz, 4ex0, 4ex1, 4exx, 4ey1, 4ey9, 4eyd, 4eyn, 4eyp, 4f0n, 4f0o, 4f1a, 4f1b, 4f1c, 4f1d, 4f1f, 4f1g, 4f4t, 4f4v, 4f51, 4f8f, 4fg3, 4fka, 4gbc, 4gbi, 4gbk, 4gbl, 4gbn, 2m1d, 4iyd, 4iyf, 2mli, 4p65, 4rxw, 2w44, 3jsd, 2vjz, 2vk0, 1uz9, 3p33, 3w7y, 3w7z, 3w80, 4xc4, 5ems, 5e7w, 5co9, 5co6, 5co2, 5cny, 5bts, 5bqq, 5bpo, 5boq - hIns A chain + B chain – human
    
  • 1fu2, 1fub - hIns A chain + B chain – powder diffraction
    
  • 2kxk, 3bxq, 1b9e, 3rov, 3u4n, 4iuz, 2m1e, 2m2m, 2m2n, 2m2o, 2m2p, 5hrq, 5hqi, 5hpu, 5hpr, 5ena, 5en9, 6ck2, 5uu4, 5uu3, 5uu2, 5usv, 5uss, 5usp, 5uru, 5urt, 5uqa, 5uoz, 1w8p, 4cxl, 4cxn, 4cy7, 4nib, 4une, 4ung, 4unh, 2wru, 2wrv, 2wrw, 2wrx, 2ws0, 2ws1, 2ws4, 2ws6,2ws7, 1qj0, 3p2x – hIns A chain + B chain (mutant)
    
  • 3ir0, 3inc, 3ilg, 3kq6, 3exx, 2r34, 2r35, 2r36, 3tt8 - hIns A chain + B chain + non-Zn metal ion
    
  • 3fq9, 1xw7, 1rwe, 1jca, 1j73, 4efx, 5t7r, 1zeh, 3zi3, 5azz - hIns A chain (mutant) + B chain
    
  • 5mwq - hIns A chain (mutant) + B chain (mutant)
    
  • 3gky, 2g4m, 1zni, 1znj, 1wav, 1iza, 1izb, 9ins, 4ins, 3ins, 3t2a, 4a7e, 3rto, 3fhp, 5lis, 5fb6, 5d5e, 5d54, 5d53, 5d52 - pIns A chain + B chain – pig
    
  • 2zpp, 2efa - pIns A chain + B chain – Neutron
    
  • 3rto, 3fhp - pIns A chain + B chain
    
  • 1m5a - pIns A chain + B chain + non-Zn metal ion
    
  • 6ins – pIns single chain
    
  • 2zp6, 1aph, 1bph, 1cph, 1dph, 4e7t, 4e7u, 4e7v, 4idw, 4bs3, 4i5y, 4i5z, 4ihn, 4m4f, 4m4h, 4m4i, 4m4j, 4m4l, 4m4m, 2a3g, 2bn1, 2bn3 - bIns A chain + B chain – bovine
    
  • 5jyq - Ins A chain + B chain – Conus geographus
    
• Insulin structures using NMR
  • 1sf1, 2aiy, 3aiy, 4aiy, 5aiy, 1ai0, 1aiy, 1xgl, 1hiq, 1hit, 2mpg, 2mvc - hIns A chain + B chain – NMR
    
  • 2hiu – apo-hIns A chain + B chain – NMR
    
  • 2kqq, 1t1k, 1t1p, 1t1q, 2mpi, 2l1y, 2l1z, 5mhd - hIns A chain (mutant) + B chain – NMR
    
  • 2jmn, 2h67, 2hh4, 2hho, 1jco, 1a7f, 2mvd, 2kjj, 2kju, 2k91, 2k9r, 2rn5 - hIns A chain + B chain (mutant) – NMR
    
  • 2jum, 2juu, 2juv, 1kmf, 1k3m, 1bzv, 1vkt, 1hui, 1mhi, 1mhj, 1hls, 1lkq - hIns A chain (mutant) + B chain (mutant) – NMR
    
  • 2jv1 – apo-hIns A chain + B chain (mutant) – NMR
    
  • 2jzq - hIns A chain – NMR
    
  • 1ho0 - hIns B chain (mutant) – NMR
    
  • 2lwz, 5bwt – hIns single chain - NMR
    
  • 5miz - bIns A chain + B chain – NMR
• Insulin complexes
  • 4xc4 - hIns A chain + B chain + sulfatide
    
  • 1ben - hIns A chain + B chain + hydroxybenzamide
    
  • 1tyl, 1tym - hIns A chain + B chain + hydroxyacetanilide
    
  • 2oly, 2om0, 2omh, 2omi - hIns A chain + B chain + urea + resorcinol
    
  • 2omg - hIns A chain + B chain + urea + cresol
    
  • 2olz, 2om1 - hIns A chain + B chain + thiocyanate
    
  • 1jk8 - hIns B chain peptide + HLA
    
  • 1zeg, 1lph - hIns A chain (mutant) + B chain (mutant) + phenol
    
  • 1qiy - hIns A chain + B chain (mutant) + phenol
    
  • 1qiz - hIns A chain + B chain (mutant) + resorcinol
    
  • 1ev3, 1ev6 - hIns A chain + B chain+ cresol
    
  • 1evr - hIns A chain + B chain + resorcinol
    
  • 3q6e - hIns A chain + B chain + synthetic receptor
    
  • 2g54, 2g56 - hIns B chain + insulin-degrading enzyme
    
  • 2wby, 2wc0, 6b3q - hIns A chain + B chain + insulin-degrading enzyme (mutant)
    
  • 3w11, 5kqv, 5wob - hIns A chain + B chain + insulin-degrading enzyme + antibody
    
  • 6ce7, 6ce9, 6ceb - hIns A chain + B chain + insulin receptor
    
  • 4oga - hIns A chain + B chain + insulin receptor + antibody
    
  • 5mam - hIns A chain + B chain + serotonin
    
  • 5mt9, 5mt3 - hIns A chain + B chain + serotonin + arginine
    
  • 1b17, 1b18, 1b19, 1b2a, 1b2b, 1b2c, 1b2d, 1b2e, 1b2f, 1b2g - pIns A chain + B chain + sulfate
    
  • 1mpj - pIns A chain + B chain + phenol
    
  • 2tci - pIns A chain + B chain + thiocyanate
    
  • 3mth - pIns A chain + B chain + methylparaben
    
  • 1zei - pIns A chain (mutant) + cresol
    
  • 7ins - pIns A chain + B chain + clupeine + cresol
    
• Proinsulin
  • 2kqp – hPIns A chain – NMR
    
  • 1t0c - hPIns A chain residues 57-87 – NMR
    
  • 1iog, 1ioh, 1sjt - hPIns A chain (mutant) + B chain (mutant) – NMR
    
  • 1efe – mini-hPIns
    
  • 1sju - mini-hPIns (mutant)
• Despeptide insulin
  • 1his - hDPI A chain + B chain]] - NMR
    
  • 1htv – hDTRI A chain + B chain
    
  • 1sdb - pDPI A chain + B chain
    
  • 1dei – pDHPI A chain (mutant) + B chain (mutant)
    
  • 1pid - bDPI A chain + B chain
    
  • 2ins – bD-Phe Ins chain A + chain B
    
  • 2ceu – DPI – yeast
    
• Leginsulin
  • 1ju8 – Lins A chain residues 1-37 – legume - NMR
    
• Insulin lispro
  • 5udp – hIns – synthetic
    
• Insulin glargine
  • 4iyd, 4iyf, 5viz – hIns – synthetic
    

Proteopedia Page Contributors and Editors (what is this?)

Jaime Prilusky, Michal Harel, Joel L. Sussman