Malate synthase

spinqualitylabelsall models Structure of malate synthase G complex with CoA, malate, Hepes and Mg+2 ion (green) (PDB entry 2gq3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Malate synthase (MS) catalyzes the reversible conversion of acetyl-CoA, glyoxylate and water to (S)-malate and CoA. MS participates in pyruvate, glyoxylate and dicarboxylate metabolism. There are 2 isozymes of MS. MS G is formed during growth on glycolate and MS A which metabolizes glyoxylate formed in the dissimilation of acetate. Structural highlights MS active site pocket is situated between the TIM barrel and the C-terminal. The ternary complex contains malate, acetyl-CoA and Mg+2 ion. Malate/Mg+2 ion binding site. Water molecules are shown as red spheres. Acetyl-CoA binding site.

3d structures of malate synthase

Updated on 29-August-2019

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• Malate synthase
  • (S), 2jqx – EcMS G (mutant) – Escherichia coli - NMR
    
  • 3cuz, 3cv1 – EcMS A
    
  • 4ex4 – MS G + Mg – Mycobacterium leprae
    
  • 5h8p – MtMS G – Mycobacterium tuberculosis
    
  • 5h8m – MtMS G (mutant) + Mg
    
  • 3cux – MS + Mg – Bacillus anthracis
    
  • 5oas – PaMS G + Mg – Pseudomonas aeruginosa
    
• Malate synthase binary complex
  • 1d8c – EcMS G (mutant) + glyoxylate + Mg
    
  • 3cv2 – EcMS A + oxalate + Mg
    
  • 1n8i – MtMS G + glyoxylate + Mg
    
  • 5h8u – MtMS G + malate + Mg
    
  • 56axe – MtMS G + acetyl CoA + Mg
    
  • 5c7v, 5cah, 5cjm, 5e9x – MtMS G (mutant) + pyrrole derivative + Mg
    
  • 5cew – MtMS G (mutant) + pyridine derivative + Mg
    
  • 5cjn – MtMS G (mutant) + quinoxaline derivative + Mg
    
  • 5dx7 – MtMS G (mutant) + isoxazole derivative + Mg
    
  • 5c9r, 5c9u, 5c9w, 5cbj, 5ccz – MtMS G (mutant) + phenyl derivative + Mg
    
  • 5c9x, 5cbi – MtMS G (mutant) + benzoate derivative + Mg
    
  • 5cak, 5cbb, 5cc3, 5cc5, 5cc6, 5cc7, 5drc, 5dri, 5ecv – MtMS G (mutant) + indole derivative + Mg
    
  • 5t8g – MtMS G (mutant) + thiophene derivative + Mg
    
  • 3s9i, 3s9z, 3sad, 3saz, 3sb0 – MtMS G (mutant) + inhibitor + Mg
    
  • 3oyx, 3pug – HvMS G + glyoxylate + Mg – Haloferax volcanii
    
  • 5tao – HvMS G + glyoxylate + Pb
    
  • 5vfb – PaMS + glycolate + Ni
    
• Malate synthase ternary complex
  • 1p7t – EcMS G (mutant) + pyruvate + Mg + acetyl-CoA
    
  • 3oyz – HvMS + pyruvate + Mg + acetyl-CoA
    
  • 1n8w – MtMS G + glyoxylate + Mg + CoA
    
  • 2gq3 – MtMS G + malate + Mg + CoA
    

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