Matriptase

spinqualitylabelsall models Structure of human matriptase catalytic domain complex with benzamidine and sulfate (PDB code 1eax). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Matriptase or suppressor of tumorigenicity 14 protein (ST14) is an epithelial-derived, membrane multi-domain serine protease. ST14 cleaves and activates hepatocyte growth factor/scatter factor and urokinase plasminogen. Benzamidine is an inhibitor of ST14. ST14 catalytic domain contains residues 615-855. Relevance ST14 has a role in ovarian cancer and is a target for anti-cancer therapy. Inflammation-associated reactive oxygen species and tissue acidity enhance ST14 activation in some skin diseases. Structural highlights ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the Ser-His-Asp catalytic triad and Gly-Ser oxyanion hole. The inhibitor benzamidine blocks the catalytic triad. Water molecules shown as red spheres. 3D Structures of matriptase Matriptase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky