P63

spinqualitylabelsall models P63 DNA-binding domain complex with DNA and Zn+2 atoms (grey) (PDB code 3us0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function p63 is a tumor protein belonging to the p53 family. It is a multi-isoform protein required for epidermal development. p63 domains structure is similar to that of p53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the p63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions. Disease Mutations in p63 result in cleft lip or palate syndromes, split hand/foot malformation or ectodermal dysplasia, . Relevance One isoform of p63 is involved in skin development and stem/progenitor cell regulation. Another isoform functions in apoptosis. Structural highlights A-B dimer interactions with DNA. Water molecules are shown as red spheres. C-D dimer interactions with DNA. Zn coordination site.

3D Structures of P63

Updated on 13-November-2019

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• p63 DBD (153-384)
  • 2rmn – hP63 - human - NMR
    
  • 3qym, 3qyn, 3us0, 3us1, 3us2 – hP63 + DNA
    
• p63 tetramerization domain (397-455)
  • 3zy0, 3zy1, 4a9z – hP63
    
  • 2nb1 – hP63 + p73 tetramerization domain - NMR
    
• p63 C terminal domain (501-575)
  • 1rg6 – hP63 - NMR
    
• p63 SAM domain (543-622)
  • 2y9t – hP63 - NMR
    
  • 2y9u – hP63 (mutant)
    
  • 5n2o – P63 (mutant) - mouse
    

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