6b11 | pdb_00006b11

TylHI in complex with native substrate 23-deoxy-5-O-mycaminosyl-tylonolide (23-DMTL)

spinqualitylabelsall models 6b11, resolution 1.99Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6b11 is a 2 chain structure with sequence from "actinomyces_fradii"_(sic)_waksman_and_curtis_1916 "actinomyces fradii" (sic) waksman and curtis 1916. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CGM, EDO, HEM NonStd Res: CSO Gene: tylH1, tylHI ("Actinomyces fradii" (sic) Waksman and Curtis 1916) Activity: 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase, with EC number 1.14.15.34 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [TYLH1_STRFR] Involved in the biosynthesis of the complex macrolide antibiotic tylosin. Catalyzes the hydroxylation of 20-oxo-5-O-beta-mycaminosyltylactone at the C-23 position to yield 5-O-beta-mycaminosyltylonolide.

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