WD repeat-containing protein

spinqualitylabelsall models Human WD-repeat protein 5 (deepskyblue) complex with histone H3 peptide (magenta) (PDB code 2h9m) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function WD repeat-containing proteins or ribosome biogenesis protein WDR (WDR) contain 4 or more repeating WD units. WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD). All WDRs form a β-propeller structure. WDRs have critical roles in many biological functions like signal transduction, transcription regulation and apoptosis. WD-repeat protein 5 (WDR5) contains 7 WD repeats. WDR5 contributes to histone modification. It may position the N-terminal of histone H3 for efficient methylation at Lys4. This methylation is implicated in the control of activation of cell lineage genes during embryogenesis. WDR5 interacts with histone-lysine N-methyltransferase (MLL). WD repeat-containing protein 48 and 20 act as regulators of deubiquinating complexes. Disease Mutant WDR is involved in triple-A syndrome. Structural highlights The histone Arg2 residue inserts into the central pore of the WDR5 β-propellor structure acting like an anchoring pin forming numerous hydrogen bonds and cation-π interactions. Water molecules are shown as red spheres.

3D Structures of WD-repeat protein

Updated on 28-March-2020

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• WDR5
  • 2gnq, 2h68, 2h14, 2h9l – hWDR5 – human
    
  • 3mxx, 3n0d, 3n0e – hWDR5 (mutant)
    
  • 3smr, 3ur4, 4ia9, 4qqe, 4ql1, 5eal, 5eam, 5eap, 5ear – hWDR5 + piperazine derivative
    
  • 6u5m, 6u5y, 6u6w, 6u80, 6u8b, 6u8l, 6u8o – hWDR5 + sulfonamide inhibitor
    
  • 6ufx, 6ucs, 6pg3, 6pg4, 6pg5, 6pg6, 6pg7, 6pg8, 6pg9, 6pga, 6pgb, 6pgc, 6pgd, 6pge, 6pgf, 5vfc, 6dar, 6das, 6d9x, 6dai, 6dak, 6e1z, 6e1y, 6e22, 6e23 – hWDR5 + inhibitor
    
  • 2cnx, 2co0, 2h6k, 2h6n, 2h6q, 2h13, 2h9m, 2h9n, 2h9p, 2g99, 2g9a, 2o9k, 3psl, 4a7j – hWDR5 + histone H3 peptide
    
  • 4gm3, 4gm8, 4gm9, 4gmb – hWDR5 + peptide inhibitor
    
  • 2xl2, 2xl3 – hWDR5 + retinoblastoma-binding protein 5 peptide
    
  • 4o45 – hWDR5 + influenza NS1 C-terminal
    
  • 4cy1 – hWDR5 + KAT8 regulatory NSL complex subunit 1+2 peptides
    
  • 4cy2 – hWDR5 + KAT8 regulatory NSL complex subunit 1 peptide
    
  • 4y7r – hWDR5 + Myc MbIIIb peptide
    
  • 3eg6, 3emh, 3uvk, 3uvl, 3uvm, 3uvn, 3uvo, 4erq, 4ery, 4es0, 4esg, 4ewr, 5sxm – hWDR5 + MLL peptide
    
  • 4erz – hWDR5 + MLL4
    
  • 6kiv, 6kiz, 6kiu, 6kix – hWDR5 in MLL1-ubNCP complex - Cryo EM
    
  • 6kiw – hWDR5 in MLL3-ubNCP complex - Cryo EM
    
  • 6pww, 6pwv – hWDR5 + MLL1 + RbBP5 + histones - Cryo EM
    
  • 6byn – hWDR5 + monobody
    
  • 3p4f – hWDR5 + retinoblastoma-binding protein 5 peptide + MLL peptide
    
  • 6iam – hWDR5 + small ubiquitin-related modifier 5
    
• WDR9
  • 2q2e – hWDR9 residues 1310-1430
    
• WDR12
  • 6p0q – hWDR12 UBL domain residues 1-87
    
  • 6n31 – hWDR12 residues 90-422
    
• WDR20
  • 5k19 – hWDR20
    
• WDR33 or pre-mRNA 3' end processing protein WDR33
  • 6f9n – hWDR33 residues 35-410 + CPSF160
    
  • 6urg – hWDR33 + CPSF160 + CPSF30 + CPSF100 - Cryo EM
    
  • 6fbs, 6fuw, 6uro – hWDR33 + CPSF160 + CPSF30 + PAS motif - Cryo EM
    
• WDR48
  • 5cvl – hWDR48
    
  • 5l8e – hWDR48 + peptide
    
  • 5l8w, 5cvn, 5cvo – hWDR48 + ubiquitin + ubiquitin carboxyl-terminal hydrolase
    
  • 5k1a, 5k1b – hWDR48 + ubiquitin carboxyl-terminal hydrolase
    
  • 5k1c, 6jlq – hWDR48 + WDR20 + ubiquitin carboxyl-terminal hydrolase
    
• WDR60
  • 6rlb, 6sc2 – hWDR60 + WDR34 + dynein + O6-alkylguanine-DNA alkyktransferase - Cryo EM
    
• WDR61
  • 3ow8 – hWDR61
    
• WDR91
  • 6vyc – hWDR91 residues 392-747
    
• WDR92
  • 3i2n – hWDR92
    
• WDR SLP1
  • 4aez – WDR + mitotic spindle checkpoint component mad2-mad3 - fission yeast
    

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