Activin receptor
From Proteopedia
Revision as of 08:50, 6 May 2020 by Michal Harel (talk | contribs)
[1] to the rescue. FunctionActivin receptors (Acvr) are integral to the activin and myostatin signalling pathway. Binding of activin to the Acvr on muscle cell membrane leads to enhanced muscle protein breakdown and debilitating loss of muscle mass and functional capacity[2]. DiseaseA mutation in Acrv1 exists in individuals with the rare developmental disorder fibrodysplasia ossificans progressiva[3]. RelevanceIncreased activin/Acvr2 signalling links aging and heart failure pathobiology and that targeted inhibition of this catabolic pathway may form a therapeutic strategy for multiple forms of hear failure[4]. Structural highlights
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3D structures of activin receptor
Updated on 06-May-2020
{"openlevels":0}
- Activin receptor type 1 or Activin receptor-like type 2 or Serine/threonine-protein kinase receptor R1 or ALK2 or BMP type 1 receptor kinase
- Activin receptor type 2
- 1bte - Acvr2 LBD 19-134 - mouse
- 1bte - Acvr2 LBD 19-134 - mouse
- Activin receptor type 2A
- Activin receptor type 2B
- Activin receptor-like type 1 or Serine/threonine-protein kinase receptor R3 or ALK1
