1odz | pdb_00001odz

Expansion of the glycosynthase repertoire to produce defined manno-oligosaccharides

spinqualitylabelsall models 1odz, resolution 1.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1odz is a 2 chain structure with sequence from "cellvibrio_cellulosa"_nagy_et_al._2002 "cellvibrio cellulosa" nagy et al. 2002. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BMA, NA, TRS, ZN, MAN Gene: manA, man26A, CJA_2770 ("Cellvibrio cellulosa" Nagy et al. 2002) Activity: Mannan endo-1,4-beta-mannosidase, with EC number 3.2.1.78 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [MANA_CELJU] Hydrolyzes mannan and galactomannan, but displays little activity towards other polysaccharides located in the plant cell wall. Appears to act in synergy with alpha-galactosidase (AgaA) to elicit hydrolysis of galactomannan. Preferentially hydrolyzes the larger oligosaccharides and has greater activity against non-substituted polysaccharides. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Mutant endo-mannanases, in which the catalytic nucleophile has been replaced, function as glycosynthases in the synthesis of manno-oligosaccharides of defined lengths. Expansion of the glycosynthase repertoire to produce defined manno-oligosaccharides.,Jahn M, Stoll D, Warren RA, Szabo L, Singh P, Gilbert HJ, Ducros VM, Davies GJ, Withers SG Chem Commun (Camb). 2003 Jun 21;(12):1327-9. PMID:12841226 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Mannosidase 3D structures

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