Chalcone synthase

spinqualitylabelsall models Alfalfa chalcone synthase containing sulfinoalanine complex with CoA and sulfate (PDB code 1d6h) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Chalcone synthase (CHS) is essential for the biosynthesis of flavonoids and anthocyanin pigments in plants. CHS condenses p-coumaroyl-CoA and three malonyl-CoA to produce the polyketide naringenin . Relevance The CHS biosynthesis product naringenin has inhibitory activity on a Cyt P450 isoform which can have carcinogenic effect and has significant antioxidant properties. Structural highlights CoA binding site. The Cys residue (3-sulfinoalanine is shown in this case) is the catalytic nucleophile tethering the starting group and the growing polyketide chain. Water molecules are shown as red spheres.

Chalcone synthase

Updated on 01-February-2021

{"openlevels":0}

• Chalcone synthase
  • 1bi5, 1u0v - alCHS 2 - alfalfa
    
  • 1d6f, 1d6i, 1i86, 1i88, 1i89, 1i8b, 1jwx - alCHS 2 (mutant)
    
  • 6dxb - AtCHS - Arabidopsis thaliana
    
  • 6dxd, 6dxe - AtCHS (mutant)
    
  • 4wum - CHS - freesia
    
  • 6dxa - CHS - pine
    
  • 6dx9 - CHS - horsetail
    
  • 7bus - sbCHS - soybean
    
  • 7dx7 - CHS - moss
    
  • 5uc5 - CHS - apple
    
  • 4yjy - CHS 1 - rice
    
  • 6dx8, 6dxc, 6dxf - CHS - Selaginella moellendorffii
    
  • 6cqb - CHS - kava
    
• Chalcone synthase complex
  • 1cgk - alCHS + naringenin
    
  • 1cgz - alCHS + resveratol
    
  • 1u0w - alCHS 2 (mutant) + resveratol
    
  • 1bq6 - alCHS + CoA
    
  • 1d6h - alCHS (mutant) + CoA
    
  • 1cml - alCHS + malonyl-CoA
    
  • 1chw - alCHS (mutant) + hexanoyl-CoA
    
  • 7bur - sbCHS + naringenin
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky