Botulinum neurotoxin 3D structures

3D structures of botulinum neurotoxin

Updated on 13-May-2021

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• Type A
  • 3bta – CbCBN + Zn – Clostridium botulinum
    
  • 3v0c - CbCBN (mutant) + Zn
    
  • 2nyy, 2nz9 - CbCBN + antibody + Zn
    
  • 3v0a, 3v0b - CbCBN (mutant) + antibody + Type A progenitor toxin + Zn
    
• Type A Light Chain residues 1-425
  • 2g7k, 2g7p, 2g7q, 2imc, 3bwi, 3bon, 3qix, 2ise, 2isg, 2ish, 4ej5, 7ky2, 7kyf, 7kyh - CbCBN LC + Zn
    
  • 5vgv - CbCBN LC + Cu
    
  • 5vgx - CbCBN LC + Hg
    
  • 3bok - CbCBN LC
    
  • 1e1h, 1xtf, 4kuf, 4el4, 4elc - CbCBN LC (mutant) + Zn
    
  • 3dse – CbCBN LC (mutant) + Zn + Ni
    
  • 1xtg - CbCBN LC (mutant) + synaptosomal-associated protein 25 + Zn
    
  • 3dda, 3ddb - CbCBN LC + synaptosomal-associated protein 25 peptide + Zn
    
  • 3zur, 3zus - CbCBN LC/synaptosomal-associated protein 25 translocation domain
    
  • 2g7n, 2ilp, 2imb, 3qiy, 3qiz, 3qj0, 4hev, 2ima, 5v8r, 6xcb, 6xcc, 6xce, 6xcf – CbCBN LC + inhibitor + Zn
    
  • 3c88, 3c89, 3c8a, 3c8b, 3boo, 3qw5, 3qw6, 3qw7, 3qw8, 3nf3 – CbCBN LC + inhibitor peptide + Zn
    
  • 4ks6, 4ktx, 5v8p, 5v8u - CbCBN LC (mutant) + inhibitor peptide + Zn
    
  • 3ds9 – CbCBN LC (mutant) + inhibitor peptide + Zn + Ni
    
  • 3k3q - CbCBN LC + antibody + Zn
    
• Type A translocation domain residues 547-871
  • 6dkk - CbCBN
    
  • 6mhj - CbCBN (mutant)
    
• Type A receptor-binding or heavy chain domain residues 871-1296
  • 2vua, 3fuo, 5tpb, 5tpc, 5lr0, 5mk6, 5mk7, 6f0o, 6f0p, 6twp, 6two, [7dvl]] – CbPBN
    
  • 4iqp – CbPBN (mutant)
    
  • 2vu9 – CbPBN + polysaccharide + Mg
    
  • 4jra, 5jlv, 5moy, 6es1 – CbCBN + synaptic vesicle glycoprotein 2C
    
  • 5jmc – CbCBN (mutant) + synaptic vesicle glycoprotein 2C
    
  • 4zjx – CbCBN + polypeptide inhibitor
    
  • 5l21 – CbCBN + VHH-C2
    
• Type A Light+Heavy Chain translocation domain residues 1-877
  • 2w2d, 3bta - CbCBN LC+HC + Zn
    
  • 6ui1, 6ul6 – CbCBN + VHH
    
• Type B
  • 1s0b, 1s0c, 1s0d, 1s0e, 1s0f, 1s0g, 1epw – CbCBN + Zn
    
  • 6g5f – CbCBN + synaptotagmin-1
    
  • 2np0 – CbCBN + synaptotagmin-2 + Zn
    
  • 6g5g – CbCBN (mutant) + synaptotagmin-2 + Mg
    
  • 1g9a, 1g9b, 1g9c, 1g9d – CbCBN + inhibitor + Zn
    
  • 1i1e – CbCBN + doxorubicin + Zn
    
  • 1f31 – CbPBN + trisaccharide + Zn
    
• Type B Light Chain residues 1-440
  • 2etf, 1f82 - CbCBN LC + Zn
    
• Type B Light+Heavy Chain translocation domain residues 1-858
  • 2xhl, 3zuq - CbCBN LC+HC + Zn
    
• Type B receptor-binding domain residues 857-1291
  • 1z0h, 6zvm – CbCBN
    
  • 6g5k, 6zvn - CbCBN + synaptotagmin-1 peptide
    
  • 6qns - CbCBN (mutant) + synaptotagmin-1 peptide
    
  • 2nm1, 4kbb - CbCBN + synaptotagmin-2 peptide
    
  • 5vid, 5vmr – CbCBN + mini-protein binder
    
  • 6uc6, 6uft, 6hut, 6ul4 – CbCBN + VHH
    
• Type C Light Chain
  • 2qn0 - CbCBN LC + Zn
    
  • 3deb - CbCBN LC (mutant)
    
• Type C receptor-binding domain
  • 3n7k, 3r4s, 3r4u - CbCBN
    
• Type D Light Chain
  • 2fpq - CbCBN LC + Zn
    
• Type D receptor-binding domain
  • 3n7j, 3obr, 3ogg - CbCBN
    
  • 3rmx, 3rmy – CbCBN (mutant)
    
  • 3obt - CbCBN + acetylneuraminic acid
    
  • 5bqm – CbCBN + somatoliberin
    
• Type D LHN domain
  • 5bqn - CbCBN
    
• Type DC Heavy Chain
  • 4isq - CbCBN HC + synaptotagmin-1 toxin-binding domain
    
  • 4isr - CbCBN HC + synaptotagmin-2 toxin-binding domain
    
• Type E
  • 3ffz, 4zkt – CbCBN + Zn
    
  • 7k7y, 7k84 - CbCBN + VHH
    
• Type E Light Chain
  • 1t3a - CbCBN LC + Zn
    
  • 1t3c, 1zkw, 1zkx, 1zl5, 1zl6, 1zn3 – CbCBN (mutant) + Zn
    
• Type F Light Chain
  • 2a8a, 2a97 - CbCBN LC + Zn
    
  • 3fie, 3fii - CbCBN LC + Zn + synaptobrevin-2
    
• Type F receptor-binding domain
  • 3rsj, 3fuq - CbCBN
    
• Type G Light Chain
  • 1zb7 - CbCBN LC + Zn
    
• Type G receptor-binding domain
  • 2vxr, 3mpp - CbCBN
    
• Type H Light Chain
  • 6bvd - CbCBN LC + Zn
    
• Type X Light Chain
  • 6f4e - CbCBN LC
    
  • 6f47, 6g8u, 6g8v - CbCBN LC + Zn
    
  • 7kz7 - CbCBN LC (mutant) + Zn
    

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Michal Harel