Function
CD23 or low affinity immunoglobulin epsilon Fc receptor or Fc fragment of IgE receptor II is a low affinity receptor of IgE and serves as an adhesion molecule involved in cell-cell interaction[1].
Disease
CD23 may be involved in the proliferation of leukemic B cells[2].
Relevance
CD23 is considered important in the differentiation of chronic lymphocytic leukemia[3].
- ↑ Bonnefoy JY, Lecoanet-Henchoz S, Gauchat JF, Graber P, Aubry JP, Jeannin P, Plater-Zyberk C. Structure and functions of CD23. Int Rev Immunol. 1997;16(1-2):113-28. doi: 10.3109/08830189709045705. PMID:9651788 doi:https://dx.doi.org/10.3109/08830189709045705
- ↑ Sarfati M. CD23 and chronic lymphocytic leukemia. Blood Cells. 1993;19(3):591-6; discussion 597-9. PMID:8018941
- ↑ DiRaimondo F, Albitar M, Huh Y, O'Brien S, Montillo M, Tedeschi A, Kantarjian H, Lerner S, Giustolisi R, Keating M. The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease. Cancer. 2002 Mar 15;94(6):1721-30. PMID:11920534