5pa0 | pdb_00005pa0

humanized rat COMT in complex with 3-hydroxy-1-methyl-5-phenylpyridin-2-one

spinqualitylabelsall models 5pa0, resolution 1.26Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5pa0 is a 1 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 7JR, CL, CXS, MG, SAH, SO4 NonStd Res: SME Gene: Comt (Buffalo rat) Activity: Catechol O-methyltransferase, with EC number 2.1.1.6 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. See Also Catechol O-methyltransferase 3D structures

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