Catechol O-methyltransferase 3D structures

3D Structures of catechol O-methyltransferase

Updated on 30-July-2025

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• Catechol O-methyltransferase
  • 4pyi, 4pyj, 4pyk – hCOMT – human
    
  • 2zlb, 4p7g, 4p7j – rCOMT – rat
    
  • 4pym – rCOMT (mutant)
    
  • 4p7f – mCOMT - mouse
    
  • 6aw4 – NgCOMT – Nannospalax galili
    
  • 6aw5, 6aw6 – NgCOMT (mutant)
    
  • 8c9t – SaCOMT – Streptomyces avermitilis
    
• Catechol O-methyltransferase binary complexes
  • 2avd – hCOMT + SAM
    
  • 2zth – rCOMT + SAM
    
  • 3u81, 4pyn, 4pyo – rCOMT (mutant) + SAH
    
  • 4pyq – rCOMT (mutant) + ureido-benzamidine
    
  • 1jr4, 3hvh, 3hvi, 3hvj, 3hvk, 3a7d, 3nw9, 3nwb, 3nwe, 5k01, 5k03, 5k05, 5k09, 5k0b, 5k0c, 5k0e, 5k0f, 5k0g, 5k0j, 5k0l, 5k0n, 5lqa, 5lqc, 5lqj, 5lqk, 5lqn, 5lqr, 5lqu, 5lr6, 6gy1 – rCOMT + inhibitor
    
  • 3oe4, 3oe5, 3ozr, 3ozs, 3ozt, 3r6t, 5p8w, 5p8x, 5p8y, 5p8z, 5p90, 5p91, 5p92, 5p93, 5p94, 5p95, 5p96, 5p97, 5p98, 5p99, 5p9a, 5p9b, 5p9c, 5p9d, 5p9e, 5p9n, 5p9o, 5p9p, 5p9r, 5p9s, 5p9t, 5p9u, 5p9v, 5p9w, 5p9x, 5p9y, 5p9z, 5pa0, 5pa1, 5pa2, 5pa3, 5pa4, 5pa5, 5pa6, 5pa7 – rCOMT (mutant) + inhibitor
    
  • 4p7k, 4pyl – rCOMT + sinefungin
    
  • 4p58 – mCOMT + inhibitor
    
  • 6aw7, 6aw8 – NgCOMT + SAH
    
  • 6aw9 – NgCOMT (mutant) + SAH
    
  • 7cvv – COMT + SAM – Niastella koreensis
    
  • 8c9s – SaCOMT + SAH
    
• Catechol O-methyltransferase ternary complexes
  • 3bwm, 3a7e, 5lsa, 6i3c – hCOMT + SAM + dinitrocatechol
    
  • 3bwy, 4xuc – hCOMT (mutant) + SAM + dinitrocatechol
    
  • 6i3d – hCOMT + sinefungin + dinitrocatechol
    
  • 4xue – hCOMT + SAM + catechol mimic
    
  • 4xuc, 4xud – hCOMT (mutant) + SAM + catechol mimic
    
  • 5fhq, 1vid – rCOMT + SAM + dinitrocatechol
    
  • 5fhr – rCOMT (mutant) + SAM + dinitrocatechol
    
  • 1h1d, 2cl5, 2zvj, 3s68 – rCOMT + inhibitor + SAM
    
  • 7xjb – rCOMT + SAM + opicapone
    
  • 7xgi – rCOMT + SAH + opicapone
    

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