3aty | pdb_00003aty

Crystal structure of TcOYE

spinqualitylabelsall models 3aty, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3aty is a 2 chain structure with sequence from Trycr. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: FMN Related: 3atz Gene: TcPGFS (TRYCR) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Old yellow enzyme (OYE) is an NADPH oxidoreductase capable of reducing a variety of compounds. It contains flavin mononucleotide (FMN) as a prosthetic group. A ternary complex structure of OYE from Trypanosoma cruzi (TcOYE) with FMN and one of the substrates, p-hydroxybenzaldehyde, shows a striking movement around the active site upon binding of the substrate. From a structural comparison of other OYE complexed with 12-oxophytodienoate, we have constructed a complex structure with another substrate, prostaglandin H(2) (PGH(2)), to provide a proposed stereoselective reaction mechanism for the reduction of PGH(2) to prostaglandin F(2alpha) by TcOYE. Structural insight into the stereoselective production of PGF2alpha by Old Yellow Enzyme from Trypanosoma cruzi.,Okamoto N, Yamaguchi K, Mizohata E, Tokuoka K, Uchiyama N, Sugiyama S, Matsumura H, Inaka K, Urade Y, Inoue T J Biochem. 2011 Nov;150(5):563-8. doi: 10.1093/jb/mvr096. Epub 2011 Aug, 12. PMID:21840922 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also NADPH dehydrogenase

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