Siderocalin

spinqualitylabelsall models Human siderocalin complex with the siderophore carboxymycobactin (PDB code 1x89) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Siderocalin (Scn) or neutrophil gelatinase-associated lipocalin binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence. Relevance Scn-NGAL levels are markedly upregulated by tissue damage. Scn-NGAL is derived from damaged kidneys. The presence of Scn-NGAL in serum or urine anticipates a severe course for the patient including the need for dialysis and the possibility of death. Structural highlights Scn-NGAL interacts with the siderophore carboxymycobactin where the latter is centered in the protein calyx making multiple interactions including cation-π bonds involving several lysines and arginine. Water molecules are shown as red spheres. Fe coordination site. 3D structures of siderocalin Siderocalin 3D structures

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