3ihy | pdb_00003ihy

Human PIK3C3 crystal structure

spinqualitylabelsall models 3ihy, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3ihy is a 5 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: PIK3C3, PIK3C3A (HUMAN) Activity: Phosphatidylinositol 3-kinase, with EC number 2.7.1.137 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Phosphoinositide 3-kinase 3D structures

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