3w8m | pdb_00003w8m

Crystal Structure of HasAp with Iron Salophen

spinqualitylabelsall models 3w8m, resolution 1.46Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3w8m is a 1 chain structure with sequence from Pseae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: YOM Related: 3w8o, 3wah Gene: hasAp, PA3407 (PSEAE) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The heme acquisition system A protein secreted by Pseudomonas aeruginosa (HasAp ) can capture several synthetic metal complexes other than heme. The crystal structures of HasAp harboring synthetic metal complexes revealed only small perturbation of the overall HasAp structure. An inhibitory effect upon heme acquisition by HasAp bearing synthetic metal complexes was examined by monitoring the growth of Pseudomonas aeruginosa PAO1. HasAp bound to iron-phthalocyanine inhibits heme acquisition in the presence of heme-bound HasAp as an iron source. Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasAp ) Bound to Synthetic Metal Complexes.,Shirataki C, Shoji O, Terada M, Ozaki S, Sugimoto H, Shiro Y, Watanabe Y Angew Chem Int Ed Engl. 2014 Mar 10;53(11):2862-6. doi: 10.1002/anie.201307889., Epub 2014 Feb 7. PMID:24604808 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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