4v7i | pdb_00004v7i

Ribosome-SecY complex.

Loading... Status: waiting for Mol* initialization Structural highlights 4v7i is a 10 chain structure with sequence from Escherichia coli, Escherichia coli K-12, Escherichia coli O157:H7 and Methanocaldococcus jannaschii. This structure supersedes the now removed PDB entries 3kc4 and 3kcr. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RL33_ECOLI Publication Abstract from PubMed During protein synthesis, it is often necessary for the ribosome to form a complex with a membrane-bound channel, the SecY/Sec61 complex, in order to translocate nascent proteins across a cellular membrane. Structural data on the ribosome-channel complex are currently limited to low-resolution cryo-electron microscopy maps, including one showing a bacterial ribosome bound to a monomeric SecY complex. Using that map along with available atomic-level models of the ribosome and SecY, we have determined, through molecular dynamics flexible fitting (MDFF), an atomic-resolution model of the ribosome-channel complex. We characterized computationally the sites of ribosome-SecY interaction within the complex and determined the effect of ribosome binding on the SecY channel. We also constructed a model of a ribosome in complex with a SecY dimer by adding a second copy of SecY to the MDFF-derived model. The study involved 2.7-million-atom simulations over altogether nearly 50 ns. Regulation of the protein-conducting channel by a bound ribosome.,Gumbart J, Trabuco LG, Schreiner E, Villa E, Schulten K Structure. 2009 Nov 11;17(11):1453-64. PMID:19913480 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Preprotein translocase Ribosomal protein S2 Ribosomal protein S21 Ribosome 3D structures

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